A simple, reversible competitive antagonist is expected to acutely: Reduce both the potency and efficacy of an agonist O Increase the potency of an agonist O Reduce the potency of an agonist Reduce the efficacy of an agonist

What effect does modification of the side chain of the following lead compound have in the modified side chain structure? OH НО. HO None of the answers It makes the agent an agonist O It makes the agent a partial agonist O It makes the agent an antagonist O It makes the agent inactive Lead compound OH Modified side chain

nafina dilute HCI Nat CEN +HCI Predict the products from the reactions of the following amines with sodium nitrile in R-CEN(nrile) + RA a) cyclohexanamine H2 RNH NH VO2 A aniline NHa

WHAT IS THE AMINE SUBSTRATE?

Which of the following statement(s) MOST closely define an agonist? An agonist is: Group of answer choices A.a substance that brings about a change in biological activity through a chemical reaction B.a specific regulatory molecule in the biological system where a drug interacts C.a drug that binds to a receptor and stimulates cellular activity D.a drug that binds to a receptor and inhibits or opposes cellular activity E. a drug that has strong affinity for the receptor and expresses high efficacy

Select two substrates and one reagent from each of the given pools to create the amine target molecule.

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Classify each amine as a primary, secondary, or tertiary.

In the design of H2 antagonist, the polar guanidine group was proposed to interact with the antagonist binding region by two hydrogen bonds. Compound A is designed based on modification of compound B and has higher antagonist activity compared to compound B. H2N NH NH2 NH HN Guanidine Guanidine HN What drug design strategy has been used here? O Rigidification O Simplification O Substituent variation O Chain Extension

Select the appropriate reagent and TWO possible substrates for the following reductive amination.