A researcher who has been studying albinism has identified a large group of families with four children in which at least one child shows albinism. None of the parents in this group of families shows albinism. Among the children, the ratio of those without albinism to those with albinism is 1.7: 1. The researcher was surprised because he thought that a 3:1 ratio would be expected on the basis of Mendel’s Principle of Segregation. a. As the research keeps increasing his sample of families with four children and at least one of the children with albinism, will the ratio of non-albino children to albino children converge toward the 3:1 ratio that he expects? Why or why not? b. What explains the non-Mendelian segregation ration in the researcher’s present data set? c. If the researcher expands his sample size to 1000 families of four children with at least one albino child, would you expect his data for non-albino vs. albino children to fit a 3:1 ratio if a chi-square test is done for a goodness-of-fit to a 3:1 ratio? Why or why not?

Human Anatomy & Physiology (11th Edition)
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Chapter1: The Human Body: An Orientation
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3. A researcher who has been studying albinism has identified a large group of families with four children in which at least one child shows albinism. None of the parents in this group of families shows albinism. Among the children, the ratio of those without albinism to those with albinism is 1.7: 1. The researcher was surprised because he thought that a 3:1 ratio would be expected on the basis of Mendel’s Principle of Segregation.

a. As the research keeps increasing his sample of families with four children and at least one of the children with albinism, will the ratio of non-albino children to albino children converge toward the 3:1 ratio that he expects? Why or why not?
b. What explains the non-Mendelian segregation ration in the researcher’s present data set?
c. If the researcher expands his sample size to 1000 families of four children with at least one albino child, would you expect his data for non-albino vs. albino children to fit a 3:1 ratio if a chi-square test is done for a goodness-of-fit to a 3:1 ratio? Why or why not?

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