A post-synaptic cell receives a signal that causes it to hyperpolarize. Which statement is NOT true about this dynamic? The cell is now more negative than it was before. O This describes an EPSP O Itwill be harder for the cell to reach threshold and generate a new action potential. O This could have been achieved through either spatial or temporal summation.

An inhibitory postsynaptic potential (IPSP) is associated with O hyperpolarization a change in sodium ion permeability opening of voltage-regulated channels O the movement of calcium ions

A loss-of-function mutation in the ion channel responsible for thegeneration of end-plate potentials results in a diminished permeabilityof the ion channel.  1)  How would you experimentally test the effect of the mutation on thefunctional properties of the cell (synapse)? You should discuss the typesof postsynaptic responses and physiological parameters you couldmeasure.

Which of the following statements are true with regards to the differences between a neuromuscular junction, and a standard central nervous system (CNS) synapse? Select all that apply. O The neuromuscular junction is a synapse between a neuron (alpha motor neuron) and a muscle fibre. CNS synapses connect two neurons. The graded potential generated by a neuromuscular junction has a much larger voltage than that of a CNS synapse. The structure of the neuromuscular junction ensures that an action potential in the alpha motor neuron always results in an action potential in the post-synaptic muscle fibre. CNS synapses do not guarantee this. The neuromuscular junction always uses Acetylcholine as a neurotransmitter, whereas CNS synapses may use a variety of neurotransmitters depending on their location and function