A form of learning disabilities and speech impairment results from a recessive mutation in the autosomal HERC2 gene. There is no known advantage or benefit to having a mutation in this gene. In a small Amish village in Ohio, about 5 per 1000 individuals are affected with this disorder. Assume this population is in Hardy-Weinberg equilibrium. Part 1 What is the frequency of the dominant (wild type) HERC2 allele in this village? O 0.995 O 0.005 O 0.07 O 0.93 Part 2 What is the frequency of heterozygotes in this village? O 0.93 O 0.07 0.13 O 0.065

Human Anatomy & Physiology (11th Edition)
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Part 5
The general population of Amish individuals across Pennsylvania and Ohio has a lower frequency of the learning
disabilities phenotype caused by the HERC2 allele (0.5 in 1000) compared to the population of the small Ohio Amish
village (5 in 1000) we have been considering so far. What is/are possible explanation(s) for the higher frequency in the
small Ohio village compared to the larger Amish population? Assume Hardy Weinberg equilibrium.
There was migration from the larger Amish population into the small village.
Unknown environmental factors changed the disease frequency in the small Ohio village population.
Other Amish communities, by chance, may have had fewer carriers in their original populations.
A founder effect could have occurred in the establishment of the small Ohio Amish population.
Transcribed Image Text:Part 5 The general population of Amish individuals across Pennsylvania and Ohio has a lower frequency of the learning disabilities phenotype caused by the HERC2 allele (0.5 in 1000) compared to the population of the small Ohio Amish village (5 in 1000) we have been considering so far. What is/are possible explanation(s) for the higher frequency in the small Ohio village compared to the larger Amish population? Assume Hardy Weinberg equilibrium. There was migration from the larger Amish population into the small village. Unknown environmental factors changed the disease frequency in the small Ohio village population. Other Amish communities, by chance, may have had fewer carriers in their original populations. A founder effect could have occurred in the establishment of the small Ohio Amish population.
A form of learning disabilities and speech impairment results from a recessive mutation in the autosomal HERC2
gene. There is no known advantage or benefit to having a mutation in this gene. In a small Amish village in Ohio, about 5
per 1000 individuals are affected with this disorder. Assume this population is in Hardy-Weinberg equilibrium.
Part 1
What is the frequency of the dominant (wild type) HERC2 allele in this village?
0.995
0.005
0.07
0.93
Part 2
What is the frequency of heterozygotes in this village?
0.93
0.07
0.13
O 0.065
Transcribed Image Text:A form of learning disabilities and speech impairment results from a recessive mutation in the autosomal HERC2 gene. There is no known advantage or benefit to having a mutation in this gene. In a small Amish village in Ohio, about 5 per 1000 individuals are affected with this disorder. Assume this population is in Hardy-Weinberg equilibrium. Part 1 What is the frequency of the dominant (wild type) HERC2 allele in this village? 0.995 0.005 0.07 0.93 Part 2 What is the frequency of heterozygotes in this village? 0.93 0.07 0.13 O 0.065
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