A critical reaction in the production of energy to do work or drive chemical reactions in biological systems is the hydrolysis of adenosine triphosphate, ATP, to adenosine diphosphate, ADP, as described by the reaction ATP(aq) + H, O(1) ADP(aq) + HPO (aq) for which AGxn = -30.5 kJ/mol at 37.0 °C and pH 7.0. Calculate the value of AGrn in a biological cell in which [ATP] = 5.0 mM, [ADP] = 0.40 mM, and [HPO?] = 5.0 mM. AGXN = kJ/mol Is the hydrolysis of ATP spontaneous under these conditions?

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A critical reaction in the production of energy to do work or drive chemical reactions in biological systems is the hydrolysis of adenosine triphosphate, ATP, to adenosine diphosphate, ADP, as described by the reaction:

\[ \text{ATP(aq)} + \text{H}_2\text{O(l)} \rightarrow \text{ADP(aq)} + \text{HPO}_4^{2-} \text{(aq)} \]

for which \(\Delta G_{\text{rxn}} = -30.5 \, \text{kJ/mol at } 37.0 \, ^\circ\text{C and pH 7.0}\). Calculate the value of \(\Delta G_{\text{rxn}}\) in a biological cell in which \([\text{ATP}] = 5.0 \, \text{mM}, [\text{ADP}] = 0.40 \, \text{mM}, \text{and } [\text{HPO}_4^{2-}] = 5.0 \, \text{mM}.\)

\(\Delta G_{\text{rxn}} =\) \_\_\_\_\_\_\_\_\_\_\_\_ \(\text{kJ/mol}\)

Is the hydrolysis of ATP spontaneous under these conditions?

- ⬜ yes  
- ⬜ no
Transcribed Image Text:A critical reaction in the production of energy to do work or drive chemical reactions in biological systems is the hydrolysis of adenosine triphosphate, ATP, to adenosine diphosphate, ADP, as described by the reaction: \[ \text{ATP(aq)} + \text{H}_2\text{O(l)} \rightarrow \text{ADP(aq)} + \text{HPO}_4^{2-} \text{(aq)} \] for which \(\Delta G_{\text{rxn}} = -30.5 \, \text{kJ/mol at } 37.0 \, ^\circ\text{C and pH 7.0}\). Calculate the value of \(\Delta G_{\text{rxn}}\) in a biological cell in which \([\text{ATP}] = 5.0 \, \text{mM}, [\text{ADP}] = 0.40 \, \text{mM}, \text{and } [\text{HPO}_4^{2-}] = 5.0 \, \text{mM}.\) \(\Delta G_{\text{rxn}} =\) \_\_\_\_\_\_\_\_\_\_\_\_ \(\text{kJ/mol}\) Is the hydrolysis of ATP spontaneous under these conditions? - ⬜ yes - ⬜ no
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