A case−control study was performed among 145 subjects with macular degeneration and 34 controls, all of whom were 70- to 79-year-old women. A genetic risk score was developed to help differentiate the cases from the controls. The risk score was categorized into six groups (1, 2, 3, 4, 5, 6), with 6 being the highest risk and 1 being the lowest risk.The data in Table 10.48 were obtained relating the risk score to case/control status.
taBlE 10.48
risk score | cases | controls |
1 | 3 | 11 |
2 | 7 | 3 |
3 | 6 | 6 |
4 | 10 | 8 |
5 | 11 | 2 |
6 | 108 | 4 |
total | 145 | 34 |
10.139 What test can be performed to study the asso- ciation between case/control status and risk score? Spe- cifically, we are interested in testing whether cases tend to have consistently higher risk scores or consistently lower risk scores than controls.
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