A 68-year-old man complains of recent changes in bowel habits and blood-tinged stools. Colonoscopy reveals a 3-cm mass in the sigmoid colon. Biopsy of the mass shows infiltrating malignant glands. These neoplastic cells have most likely acquired a set of mutations that cause which of the following changes in cell behavior? (A) Decreased cellular motility (B) Enhanced stem cell differentiation (C) Increased cell-cell adhesion (D) Increased susceptibility to apoptosis (E) Loss of cell cycle restriction point control

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