Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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84) An antimicrobial is described as preventing alanine-alanine bridge formation. This means it
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- You are a bacteriologist studying a pathogenic protein (the “BAD” protein) that contributes to diseases caused by Staphylococcus aureus. BAD functions as an ab heterodimer, and the a subunit (25kD) and b subunit (75kD) are held together by an electrostatic interaction between K in the a subunit and D in the b subunit. You are trying to dissociate the BAD subunits to prevent pathogenesis in the bacteria. Which mutation would you make to prevent the BAD subunits from forming a dimer? Assume neutral pH. (A) introduce AAA to AGA point mutation in the a subunit gene(B) introduce GAC to GAG point mutation in the b subunit gene(C) introduce GAT to CGT point mutation in the b subunit gene(D) introduce two point mutations: AAG to GTG in the a subunit gene & GAC to CTC in the b subunit gene (E) introduce two point mutations: AAA to TGC in the a subunit gene & GAT to TGT in the b subunit genearrow_forwardCovid-19 may be regarded as a hazardous biological agent. why? (brief summary)arrow_forwardWith which kind of antibiotic (static or cidal) would you expect the MIC and MBC to be about the same concentration and to be vastly different concentrationsarrow_forward
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