8. Lack oг 3-BPG can be deadly. A) What is 2,3-BPG? How is it produced and why does hemoglobin need 2,3- ВPG? B) Under what physiological conditions are blood levels of 2,3-BPG elevated? C) How does an increased level of 2,3-BPG help our bodies compensate through crises of a low availability of external oxygen? Highlight the action of 2,3-BPG on hemoglobin in your answer.

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Chapter11: The Blood
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Hemoglobin
poz in
lungs
tissues (4,500 m)
po2 in
lungs
(sea level)
po2 in
8. Lack of 2,3-BPG can be deadly.
1.0
BPG = 0 mM
38%
A) What is 2,3-BPG? How is it produced and why does hemoglobin need 2,3-
30%
ВPG?
37%-
Y 0.5
B) Under what physiological conditions are blood levels of 2,3-BPG elevated?
C) How does an increased level of 2,3-BPG help our bodies compensate through
crises of a low availability of external oxygen? Highlight the action of 2,3-BPG
on hemoglobin in your answer.
BPG - 5 mM at sea level
BPG 8 mM at high altitudes
(4,500 m)
4
8
12
16
pO2 (kPa)
Figure 5-17
Lehninger Principles of Biochemistry, Seventh Edition
O 2017 W. H. Freeman and Company
Transcribed Image Text:Hemoglobin poz in lungs tissues (4,500 m) po2 in lungs (sea level) po2 in 8. Lack of 2,3-BPG can be deadly. 1.0 BPG = 0 mM 38% A) What is 2,3-BPG? How is it produced and why does hemoglobin need 2,3- 30% ВPG? 37%- Y 0.5 B) Under what physiological conditions are blood levels of 2,3-BPG elevated? C) How does an increased level of 2,3-BPG help our bodies compensate through crises of a low availability of external oxygen? Highlight the action of 2,3-BPG on hemoglobin in your answer. BPG - 5 mM at sea level BPG 8 mM at high altitudes (4,500 m) 4 8 12 16 pO2 (kPa) Figure 5-17 Lehninger Principles of Biochemistry, Seventh Edition O 2017 W. H. Freeman and Company
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