78. Which situation(s) might result in a higher than expected plasma drug concentration? a. Enzyme induction b. Enzyme saturation c. Competitive inhibitors of metabolizing enzymes d. A and B e. B and C
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- 6) The maximum plasma concentration of a drug is reached when a. The elimination rate equals the absorption rate b. The elimination rate is very high c. The elimination rate is lower than the absorption rate d. The elimination rate is minimum e. The absorption far exceeds the elimination rate4) In Drug Plasma Concentration curves, the Area Under Curve represents a. Total amount of drug administrated b. Total amount of drug absorbed from the GI tract c. Total amount of drug available to the target tissues d. Total amount of drug that reaches the systemic circulation e. Total amount of drug that will be eliminated through the kidneysWhich of the following events cannot increase the bioavailability of a drug? A. Patients suffer from cirrhosisB. Patients suffer from diarrheaC. Switch to intravenous injection from oral administration D. Switch to sustained-release formulations E. Switch to formulation with carriers
- The half-life of a drug has been determined to be 6 hours. The initial drug concentration was measured at 36mg%. What will the drug concentration be after 3 half-lifes? 10. A. 18mg% B. 9mg% C. 3mg% D. 4.5mg%A dose-limiting toxicity is: to A. B. a severe side effect that a patient cannot tolerate without life threatening risks. C. the total dose of a drug given throughout a cycle of treatment. D. a known and expected side effect that is unwanted and unpleasant. the total amount of a specific drug that is safely given over a patient's lifetime.Drug X has a toxic dose of 100mg/kg and a therapeutic dose of 10mg/kg. Drug Y also has a toxic dose of 100mg/kg but a therapeutic dose of 20mg/kg. A. What is the chemotherapeutic index of drug X and drug Y? B. Which drug would be preferred to be used by physicians and why?
- You are administering tramadol to your patient. The order is for 600 mg. There are (3) concentrations available: a 300 mg/tab; a 200 mg/tab and a 100 mg/tab. Which concentration would be your best choice? How many tablets will you give? Group of answer choices a. 100 mg/tab; give 6 tablets b. 300 mg/tab; give 2 tablets c. 100 mg/tab; give 1 tablet d. 300 mg/tab; give 1/2 tablet e. 200 mg/tab; give 3 tablets f. 200 mg/tab; give 1/3 tabletThe total dosage amount that is given to a patient in a day to achieve therapeutic effect. a. Minimum dose b. Maintenance dose c. Daily dose d. Single dose100 mg dose of Drug X is administered via IV at 7 hours, blood drug concentration is 5 mcg/mL Half-life of the Drug X is 5 hours A. Find the blood concentration after 6 hours if the dose is 1g (should be between 50.39 and 61.6) B. Minimum effective concentration is 2 mcg/mL. IF the first dose was 100mg of Drug X, how many hours after the dose would reach to 2mcg/mL. (When should the 2nd dose be given). (should be between 12.06 and 14.74)
- Please choose all the ADVANTAGES of protein-based drugs such as antibodies compare to small molecules from the following options. A. high selectivity B. Biocompatibility C. stable to metabolism D. oral bioavailability E. long half-life F. high activityWhat are the safety guidelines for vincristine preparation and administration? A. Use an infusion pump to administer intravenously over 25-50 minutes. B. Prepare in a minibag and infuse intravenously over 5-15 minutes. C. Dilute in a 10ml syringe with normal saline and administer IV push. D. Reconstitute in a minibag of 5% dextrose in water and administer IV push.Doctor's Order: Nafcillin 500 mg po pc; Available: Nafcillin 1 gm tab (scored). How many tab will you administer per day? a. 2.5 tabs IF b. 2 tabs c. 1.5 tabs d. 1 tab ANSWER: COMPUTATION : Doctor's Order: Synthroid 75 mcg po daily; Available: Synthroid 0.15 mg tab (scored). How many tab will you administer? 1 tab a. b. 0.5 tab c. 2 tabs d. 1.5 tabs ANSWER: COMPUTATION : Doctor's Order: Diuril 1.8 mg/kg po tid; Available: Diuril 12.5 mg caps. How many cap will you administer for each dose to a 31 lb child? a. 2 caps b. 2.5 caps c. 3 caps d. 1.5 caps ANSWER: COMPUTATION : Doctor's Order: Cleocin Oral Susp 600 mg po qid; Directions for mixing: Add 100 mL of water and shake vigorously. Each 2.5 mL will contain 100 mg of Cleocin. How many tsp of Cleocin will you administer? 3 tsp 5 tsp 3.5 tsp a. b. c. d. 1 tsp ANSWER: MPUTATION: