5 Are the pairs of structures shown below constitutional isomers, enantiomers, diastereomers, or the same? What is the degree of unsaturation for the compound in entry (e)? (a) (b) Et Et (c) (d) H3C (e) (f) Me -Me "OH FOH Me ОН Me Degree of unsaturation =

Hypoglycin A, an amino acid derivative found in unripened lychee, is an acutely toxic compound that produces seizures, coma, and sometimes death in undernourished children when ingested on an empty stomach. (a) Draw the neutral, positively charged, and negatively charged forms of hypoglycin A. (b) Which form predominates at pH = 1, 6, and 11? (c) What is the structure of hypoclycin A at its isoelectric point?

(b) The structure of a drug called tirbanibulin which is used to treat a pre-cancerous skin condition called actinic keratosis is shown below. (i) (ii) (iii) (iv) ہے مههممنن State Lipinski's Rule of Five (ROF) and Veber's addition to the ROF. Briefly state why the ROF is used in medicinal chemistry?. Given that the molecular mass of tirbanibulin is 431.536 g.mol-¹ and its log P is 3.2, apply the ROF and Veber's additional rule to this drug and show clearly how you arrived at your answer. Comment on the outcome of your analysis of the structure in part (iii).

6.16 Use the projection operator method to determine the SALCS required for formation of o bonds in (a) BF,, (b) PF,. 5*