
Chemistry
10th Edition
ISBN: 9781305957404
Author: Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher: Cengage Learning
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Transcribed Image Text:4- Give one example of Williamson ether synthesis. Show the reactants materials and
the product. Draw the reaction mechanism?
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- Q4. Alkyl halides are good at doing substitution (SN2/SN1) and elimination (E1/E2) reactions because the halide (X-) is a good LG. Alcohols on the other hand are not suitable for these reactions since hydroxide (¯OH) is a poor LG. However, an OH can be converted into a OTs (tosyl group) by reacting an alcohol with TsCl in presence of a base. An OTs is a good LG, and this allows us to indirectly (via OTs) use alcohols in substitution (SN2/SN1) and elimination (E1/E2) reactions. (4) OH TsCl NEt3 OTS Tosyl ester NaCN DMSO + HNEt3 Determine the major/minor products CH3OH heat OTS Tosyl ester TsCl = NaOCH3 CH3OH DBU Ś=0 CIarrow_forwardComplete the following nucleophilic substitution reactions. In each reaction, show all electron pairs on both the nucleophile and the leaving group.arrow_forwardWhat should be used to complete the following reaction? H₂C. O 1) CH3CH₂CH2OH, NaBH4 2) H3O+ NaOH, H₂O H₂C OCH3CH₂CH20", CH3CH₂CH₂OH O 1) CH3CH2CH₂MgBr, ether 2) H3O+ H₂C OHarrow_forward
- 1) For each reaction below, provide the product and type (ketone/aldehyde/enol/enolate) of the reactant and the product. The equilibrium arrows are generic: a) Type b) Type c) Type d) Type OH 0}₁ OH H3O* catalyst H₂O H3O* catalyst H₂O OH catalyst H₂O OH catalyst H₂O Product Type Product Type Product Type Product Typearrow_forwardWhat starting material is needed for reaction 1? ... Reaction 1 Reaction 2 A H2 H20 B Lindlar's Catalyst H3PO4 A Benzene B Pent-2-ene Pent-2-yne D Pentanearrow_forward6) Determine the reagents Needed, show each step. Br HOLLarrow_forward
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