2. Will the following reaction occur as written? HO, NH H2N cat. H2SO4 A) Yes, after initial protonation of the carbonyl oxygen, ethanol is added to open the lactam. B) No, the lactam would dimerize under these conditions. C) Yes, cyclic amides can easily be converted to esters due to the ring strain. D) No, ring opening of the lactam does not occur since the protonation of the nitrogen occurs more readily than protonation of the carbonyl oxygen.

2. Will the following reaction occur as written? HO, NH H2N cat. H2SO4 A) Yes, after initial protonation of the carbonyl oxygen, ethanol is added to open the lactam. B) No, the lactam would dimerize under these conditions. C) Yes, cyclic amides can easily be converted to esters due to the ring strain. D) No, ring opening of the lactam does not occur since the protonation of the nitrogen occurs more readily than protonation of the carbonyl oxygen.

Introduction to General, Organic and Biochemistry

11th Edition

ISBN:9781285869759

Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Chapter18: Carboxylic Acids

Section: Chapter Questions

Problem 18.36P

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