2. The homozygous mutant a, an allele of the albinism gene in the mouse, has a white coat and dark eyes. The homozygous mutant p has pink eyes. Mice of genotype a+/+p are testcrossed with mice homozygous for the two mutations. The progeny obtained are shown below. Calculate the recombination frequency and map distance between the two genes. Phenotype of Progeny White coat, dark eyes White coat, pink eyes Dark coat, white eyes Dark coat, pink eyes Number 240 31 34 474

4.

2. A pedigree of a rare disease associated with a mutation (deletion) in a genomie imprintedsutosomal gene is shown below. Individuals with the deletion and disease are shown in color,while those with the deletion but unaffected are indicated by dots. 1 2 I 1 2 II 1 2 3 4 III IV 1 3 4 5 8 V 2 5 8 9 12 13 14 15 1) What type of genomic imprinting is shown, why (1 point)? 2) Given that "A" to represent the normal allele and "A-" to represent the deletion allele, pleasespecify the possible genotype of the labeled individuals (4 points). (From I-1 to V-16,thirty-two in total. You need to distinguish the allele inherited from father and mother) 3) Explain the phenotype of IV-1, IV-2, V-3, V-11, and V-13. (3 points) 4) What is the probability that the offspring of V-5 will exhibit the disease? What about V-14?(2 points)

4. You have two probes that detect RFLPS that are closely linked (that is, RFLP 1 and 2 tend to be passed on together). You have been asked to help settle a paternity case. The two possible fathers have the following RFLP pedigree. The child and mother are also probed with these two RFLP probes. Is one male more likely to be the father? If so, which one? Explain your reasoning. (The data below the pedigree are two Southern blots.) grandparents grandparents dad #1 dad #2 child mother Probe #1 Probe #2 ||

1. A mechanism for equalizing the expression of X-linked genes in males and females of a species.              [ Choose ]             Conjugation             Reciprocal Crosses             Transduction             Binary Replication             Haplotype             Interference             Transformation             Gain of Function Mutation             Allelic Series             Blending Theory             Dosage Compensation             Rolling Circle Replication             Pleiotropy             Coefficient of Coincidence             Reciprocal Cross             Loss of Function Mutation             Synaptonemal Complex             Allelic Phase             Allele             Chiasma             Law of Independent Assortment            2. A group of alleles of a gene that show a hierarchy of dominance relationship among them.              [ Choose ]             Conjugation             Reciprocal Crosses             Transduction             Binary Replication…

2. How many genetically different kinds of gametes can an individual with each of the following genotypes produce? Assume each gene is on a separate pair of chromosomes. a. Genotype AA aa Aa AaBB Number of genetically different gametes Genotype Aa Bb AaBbCC Aa Bb Cc AaBb CcDdEeFf Number of genetically different gametes Given the information in the table above, what general rule exists for determining the number of different gametes an organism of a given genotype can produce? Explain.