2. Reactivity of Carboxylic Acid Derivatives a. Rank the following carboxylic acid derivatives in order from LEAST reactive to MOST reactive when they undergo nucleophilic acyl substitution reactions. If two are close/equal in reactivity, please change the "<" to an "" sign in your ranking. `NH2 CI HO. A C E b. Justify your answer thoroughly in words. Your explanation should include, if applicable, leaving group ability, base strength, conjugate acid strengths, pKa values, etc.

20:33 1 : ●●● all the proper notations for depicting resonance. 4. Provide the full mechanism (curved arrows and intermediates) that leads to the product in the scheme below. Draw the structure of the product to help you see how the starting materials will combine. Use that as a clue to figure out how to draw the mechanism arrows. ccare in your scheme. Be sure to use NaOEt 00 i 5. Provide the major organic product of the reaction shown. Determine if these conditions are best for SN2, SN1, E2, or E1. Be sure to indicate stereochemistry by using the proper wedges/dashes in the product. acetone phenyl butanoate Send a chat O

Draw the product(s) of the following acid-base reaction OH You do not have to consider stereochemistry • You do not have to explicitly draw Hatoms. You should include all products. HOSOH - References) . If the reaction is a Lewis acid-base reaction, draw the products in a single sketcher, with a single bond connecting the Lewis base and Lewis acid If the reaction is a Brensted acid-base reaction, draw the products in separate sketchers Separate multiple products using the sign from the drop-down menu ChemDoodle २२५ 00-fair

1. Rank the following molecules in terms of increasing acidity. Explain your rankings in terms of stability of the corresponding conjugate base. OH HO, SH NaNH2 =H HO,

Give detailed Solution with explanation needed. don't use Ai for answering this

5. Tropone (A) is much stronger base (conjugate acid more stabilized) than the open chain, conjugated ketone (B), both shown below. Please explain briefly why this observation makes sense. H2C CCH2 A В

Rank the acidity of each of these compounds from least to most acidic. The explicitly drawn Hydrogens should be compared. What would be a small explanation as to why they are ranked in that order?

An organic chemistry experiment involves a nucleophilic substitution (SN2) reaction using 1-iodobutane and 2-naphthoxide ion. The 2-naphthoxide ion is generated from 2-naphthol and sodium hydroxide in an ethanol solvent. The experiment includes steps like generating the nucleophile, conducting the SN2 reaction, and analyzing the product using 1H NMR spectroscopy. Question: On the 1H NMR spectra (attached), draw the structure of the product and assign the peaks. Label the unique protons with different letters and write those same letters by the peaks in the NMR spectrum.

4. Arrange the compounds in the following set in order of increasing basicity (1-the most basic; 3-the least basic). Explain your answer! Magnesium hydroxide, magnesium acetate, methylmagnesium bromide