2. A 4-year-old girl was diagnosed with thiamine deficiency and the symptoms include tachycardia, vomiting, convulsions. Laboratory examinations revcal high levels of pyruvate, lactate and a-ketoglutarate. Explain which coenzyme is formed from vitamin B, and its role in oxidative decarboxylation of pyruvate. For that: a) describe the structure of pyruvate dehydrogenase complex (PDH) and the cofactors that it requires; b) discuss the symptoms which are connected with the thiamine deficiency and its effects on PDH and a-ketoglutarate dehydrogenasc complex; c) explain the changes in the levels of mentioned metabolites in the blood;
2. A 4-year-old girl was diagnosed with thiamine deficiency and the symptoms include tachycardia, vomiting, convulsions. Laboratory examinations revcal high levels of pyruvate, lactate and a-ketoglutarate. Explain which coenzyme is formed from vitamin B, and its role in oxidative decarboxylation of pyruvate. For that: a) describe the structure of pyruvate dehydrogenase complex (PDH) and the cofactors that it requires; b) discuss the symptoms which are connected with the thiamine deficiency and its effects on PDH and a-ketoglutarate dehydrogenasc complex; c) explain the changes in the levels of mentioned metabolites in the blood;
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Transcribed Image Text:2. A 4-year-old girl was diagnosed with thiamine deficiency and the symptoms
include tachycardia, vomiting, convulsions. Laboratory examinations reveal
high levels of pyruvate, lactate and a-ketoglutarate. Explain which coenzyme
is formed from vitamin B, and its role in oxidative decarboxylation of pyruvate.
For that:
a) describe the structure of pyruvate dehydrogenase complex (PDH) and the
cofactors that it requires;
b) discuss the symptoms which are connected with the thiamine deficiency and
its effects on PDH and a-ketoglutarate dehydrogenase complex;
c) explain the changes in the levels of mentioned metabolites in the blood;
d) name the deseribed discase,
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