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2) This diagram shows the signaling pathway involved in transducing extracellular matrix (ECM) signals to induce S-phase progression. Briefly: ECM (shown in green) binds to and activate integrins which bind to and activate Ras which binds to and activate Raf which binds to and activate MEK, which.... etc (you get the idea) until Erk activates cyclinD which the form a complex with CDK4/6. For the purpose of this problem, we consider that the signals provided by the ECM through this pathway are necessary and sufficient for the cell to enter S phase. 料 Erk Integrin S phase Erk Ras Raf MEK Cyclin ← Cyclin D CDK48 A) In your studies of the cell cycle, you isolated a new cell line called mutRAS2 cells. Unlike normal wild type cells, you find that Ras is always bound to GTP in mutRAS2 cells. Describe how the cell cycle differs between mutRAS2 cells and normal cells when ECM is not present. Explain your reasoning: B) In another mutant cell (named mutCD2), you found that a cyclinD mutation causes the value of the Kd of the CyclinD-CDK4/6 complex to increase more than a 1000 fold. This mutated cyclin D still requires activation by Erk. What effect will this mutation likely have on the ability of mutCD2 cells to enter S-phase when exposed to extracellular matrix? Answer: What effect will this mutation likely have on the ability of mutCD2 cells to enter S-phase when no ECM is around the cell? Answer:

2) This diagram shows the signaling pathway involved in transducing extracellular matrix (ECM) signals to induce S-phase progression. Briefly: ECM (shown in green) binds to and activate integrins which bind to and activate Ras which binds to and activate Raf which binds to and activate MEK, which.... etc (you get the idea) until Erk activates cyclinD which the form a complex with CDK4/6. For the purpose of this problem, we consider that the signals provided by the ECM through this pathway are necessary and sufficient for the cell to enter S phase. 料 Erk Integrin S phase Erk Ras Raf MEK Cyclin ← Cyclin D CDK48 A) In your studies of the cell cycle, you isolated a new cell line called mutRAS2 cells. Unlike normal wild type cells, you find that Ras is always bound to GTP in mutRAS2 cells. Describe how the cell cycle differs between mutRAS2 cells and normal cells when ECM is not present. Explain your reasoning: B) In another mutant cell (named mutCD2), you found that a cyclinD mutation causes the value of the Kd of the CyclinD-CDK4/6 complex to increase more than a 1000 fold. This mutated cyclin D still requires activation by Erk. What effect will this mutation likely have on the ability of mutCD2 cells to enter S-phase when exposed to extracellular matrix? Answer: What effect will this mutation likely have on the ability of mutCD2 cells to enter S-phase when no ECM is around the cell? Answer:

Biology 2e
Biology 2e
2nd Edition
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark
Chapter9: Cell Communication
Section: Chapter Questions
Problem 1VCQ: Figure 9.8 HER2 is a receptor tyrosine kinase. In 30 percent of human breast cancers, HER2 is...
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2) This diagram shows the signaling pathway involved in transducing extracellular matrix (ECM) signals to induce S-phase progression. Briefly: ECM (shown in green) binds to and activate integrins which bind to and activate Ras which binds to and activate Raf which binds to and activate MEK, which.... etc (you get the idea) until Erk activates cyclinD which the form a complex with CDK4/6. For the purpose of this problem, we consider that the signals provided by the ECM through this pathway are necessary and sufficient for the cell to enter S phase. Erk Integrin Erk Ras Raf MEK Cyclin D Cyclin D CDK4/6 S phase A) In your studies of the cell cycle, you isolated a new cell line called mutRAS2 cells. Unlike normal wild type cells, you find that Ras is always bound to GTP in mutRAS2 cells. Describe how the cell cycle differs between mutRAS2 cells and normal cells when ECM is not present. Explain your reasoning: B) In another mutant cell (named mutCD2), you found that a cyclinD mutation causes the value of the Kd of the CyclinD-CDK4/6 complex to increase more than a 1000 fold. This mutated cyclin D still requires activation by Erk. What effect will this mutation likely have on the ability of mutCD2 cells to enter S-phase when exposed to extracellular matrix? Answer: What effect will this mutation likely have on the ability of mutCD2 cells to enter S-phase when no ECM is around the cell? Answer:
Transcribed Image Text:2) This diagram shows the signaling pathway involved in transducing extracellular matrix (ECM) signals to induce S-phase progression. Briefly: ECM (shown in green) binds to and activate integrins which bind to and activate Ras which binds to and activate Raf which binds to and activate MEK, which.... etc (you get the idea) until Erk activates cyclinD which the form a complex with CDK4/6. For the purpose of this problem, we consider that the signals provided by the ECM through this pathway are necessary and sufficient for the cell to enter S phase. Erk Integrin Erk Ras Raf MEK Cyclin D Cyclin D CDK4/6 S phase A) In your studies of the cell cycle, you isolated a new cell line called mutRAS2 cells. Unlike normal wild type cells, you find that Ras is always bound to GTP in mutRAS2 cells. Describe how the cell cycle differs between mutRAS2 cells and normal cells when ECM is not present. Explain your reasoning: B) In another mutant cell (named mutCD2), you found that a cyclinD mutation causes the value of the Kd of the CyclinD-CDK4/6 complex to increase more than a 1000 fold. This mutated cyclin D still requires activation by Erk. What effect will this mutation likely have on the ability of mutCD2 cells to enter S-phase when exposed to extracellular matrix? Answer: What effect will this mutation likely have on the ability of mutCD2 cells to enter S-phase when no ECM is around the cell? Answer:
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