1.Please talk about 3 types of white blood cells and what their functions are.2. Please talk about what occurs to attain a fever. What is your body responding to? How can a fever be beneficial? How can it be treated?

3. Complete the chart below by filling in the broad characteristics of each family of cytokines and which type of cell that secretes each one. Family name Interleukin-1 Class 2 (interferon) Class 1 (hematopoietin) IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-12, IL-13, IL-15, IL-21, IL-23, Representative members Characteristics Cell type that releases Interleukin-17 IL-1a, IL-1B, IL-Ra, IL- 18, IL-33 Chemokines GM-CSF, G-CSF, growth hormone, prolactin, erythropoietin, hematopoietin Tumor necrosis factor TNF-a, TNF-B, CD40L, Fas (CD95), BAFF, APRIL, LT-B IL-17 (IL-17A), IL-17B, IL-17C, IL-17D, IL-17F IL-8, CCL 19, CCL21, RANTES, CCL2 (MCP- 1), CCL3 (MIP-1a) IFN-α, IFN-ß, IFN-y, IL- 10, IL-19, IL-20, IL-22, IL-24

Multiple Sclerosis is characterized by ? 1. A demyelination of the Neuron2. Leaking of the electrical signal down the axon3. In multiple sclerosis (MS), the body's immune system T cells attack the myelin sheath that protects the nerve fibers. This is an autoimmune reaction.4. All of the above

1. Tolerance plays a critical role in the adaptive immune system. Immune cells should not recognize host (or self) antigens. What mechanisms are available to remove lymphocytes with receptors that do recognize self antigens? 2. Explain how an individual’s first and subsequent exposures to an allergen differ by describing how the immune system responds to exposure. Answer both questions please