Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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1. Proteoglycans, such as heparan sulfate are defined as having
sulfated glycosaminoglycans that are covalently joined to membrane
proteins or secreted proteins.
a. Which weak intermolecular force of attraction allows the
proteoglycans to interact with extracellular proteins, such as
antithrombin (AT) in the diagram below?
b. Provide the full name of the moiety on the proteoglycan that
interacts with the protein.
c. Provide the name of one of the amino acid residues within the
protein (AT) that is likely to interact with the proteoglycan
Conformational activation
Factor Xa
AT Heparan
sulfate
- NS domain
A conformational change induced in the protein
antithrombin (AT) on binding a specific
pentasaccharide NS domain allows its interaction
with blood clotting factor Xa, preventing clotting.
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Transcribed Image Text:1. Proteoglycans, such as heparan sulfate are defined as having sulfated glycosaminoglycans that are covalently joined to membrane proteins or secreted proteins. a. Which weak intermolecular force of attraction allows the proteoglycans to interact with extracellular proteins, such as antithrombin (AT) in the diagram below? b. Provide the full name of the moiety on the proteoglycan that interacts with the protein. c. Provide the name of one of the amino acid residues within the protein (AT) that is likely to interact with the proteoglycan Conformational activation Factor Xa AT Heparan sulfate - NS domain A conformational change induced in the protein antithrombin (AT) on binding a specific pentasaccharide NS domain allows its interaction with blood clotting factor Xa, preventing clotting.
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