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1. A)( The product of the reaction below has been found to be a potent anticancer agent (J.Med. Chem. 2010, 6867). Predict the structure of the product of the following reaction. (Hint: reaction similar to -OH group with TSCI) CN 1 equiv. B) The following substrate is a starting material in the synthesis of compounds having opiod activity (J. Med. Chem. 2011, 957). Show all products that would result from the reaction below. (Hint : think of elimination - 3 possible products ) 1) excess CHI / NaHCO, NH 2) Ag20/ H20 Hyco 3) heat

1. A)( The product of the reaction below has been found to be a potent anticancer agent (J.Med. Chem. 2010, 6867). Predict the structure of the product of the following reaction. (Hint: reaction similar to -OH group with TSCI) CN 1 equiv. B) The following substrate is a starting material in the synthesis of compounds having opiod activity (J. Med. Chem. 2011, 957). Show all products that would result from the reaction below. (Hint : think of elimination - 3 possible products ) 1) excess CHI / NaHCO, NH 2) Ag20/ H20 Hyco 3) heat

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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1. А The product of the reaction below has been found to be a potent anticancer agen (J.Med. Chem. 2010, 6867). Predict the structure of the product of the following reaction. (Hint: reaction similar to -OH group with TsCl) CN 1 equiv. Ph H B) The following substrate is a starting material in the synthesis of compounds having opiod activity (J. Med. Chem. 2011, 957). Show all products that would result from the reaction below. (Hint : think of elimination - 3 possible products ) 1) excess CHI / NaHCO3 NH 2) Ag20 / H20 H,co 3) heat
Transcribed Image Text:1. А The product of the reaction below has been found to be a potent anticancer agen (J.Med. Chem. 2010, 6867). Predict the structure of the product of the following reaction. (Hint: reaction similar to -OH group with TsCl) CN 1 equiv. Ph H B) The following substrate is a starting material in the synthesis of compounds having opiod activity (J. Med. Chem. 2011, 957). Show all products that would result from the reaction below. (Hint : think of elimination - 3 possible products ) 1) excess CHI / NaHCO3 NH 2) Ag20 / H20 H,co 3) heat
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