1. Bicyclic keto compounds such as camphor react predictably with nucleophiles according to steric influences; this effect has been termed steric approach control. In contrast, the reaction of nucleophiles with simple acyclic and monocyclic keto compounds are influenced primarily by thermodynamic factors; this effect has been termed product development control. Given the following reaction, predict the identity of the major product and provide a rationale for your selection. OH NaBH4 t-Bu. t-Bu. t-Bu HO. ELOH 1 2

1. Bicyclic keto compounds such as camphor react predictably with nucleophiles according to steric influences; this effect has been termed steric approach control. In contrast, the reaction of nucleophiles with simple acyclic and monocyclic keto compounds are influenced primarily by thermodynamic factors; this effect has been termed product development control. Given the following reaction, predict the identity of the major product and provide a rationale for your selection. OH NaBH4 t-Bu. t-Bu. t-Bu HO. ELOH 1 2

Chemistry

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ISBN:9781305957404

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Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Sulfur Functional Groups

Many organic molecules contain sulfur functional groups and have their own importance in chemistry as well as biology. Some of the organic molecules which contain sulfur functional groups and the corresponding sulfur functionality is given below:

Question

1. Bicyclic keto compounds such as camphor react predictably with nucleophiles according to steric influences;
this effect has been termed steric approach control. In contrast, the reaction of nucleophiles with simple
acyclic and monocyclic keto compounds are influenced primarily by thermodynamic factors; this effect has
been termed product development control. Given the following reaction, predict the identity of the major
product and provide a rationale for your selection.
ОН
NABH4
t-Bu.
t-Bu
t-Bu.
ELOH
1
2

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