Chemistry
Chemistry
10th Edition
ISBN: 9781305957404
Author: Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher: Cengage Learning
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1. Answer ALL parts of this question.
OH
Ph
Ph
1
Figure Q1
(a) Provide a two-step retrosynthetic analysis of the fenpiprane analogue 1
(Figure Q1). In your answer account for all synthons and synthetic
equivalents, and label the two retrosynthetic arrows, indicting the type of
disconnection taking place
(b) Draw the two reaction schemes with viable reagents required for the
synthesis of 1.
(c) Give plausible curly arrow mechanisms for both reactions in the sequence
drawn in part (b) required to make 1.
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Transcribed Image Text:1. Answer ALL parts of this question. OH Ph Ph 1 Figure Q1 (a) Provide a two-step retrosynthetic analysis of the fenpiprane analogue 1 (Figure Q1). In your answer account for all synthons and synthetic equivalents, and label the two retrosynthetic arrows, indicting the type of disconnection taking place (b) Draw the two reaction schemes with viable reagents required for the synthesis of 1. (c) Give plausible curly arrow mechanisms for both reactions in the sequence drawn in part (b) required to make 1.
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