Describe how the mismatch excision-repair pathway corrects errors introduced during replication. The following steps can be used for description of this process: Step 1: Damage recognition; Step 2: Unwinding and excision; and Step 3: Gap repair by D N A polymerase and ligase. 1MSH2MSH6Template strand5'A3'Newly synthesizeddaughter strandMLH1 endonuclease,PMS22DNA helicaseDNA exonuclease5'3'5'3'Gap repair by DNApolymerase and ligase35'3'A|IT|||3'5'31Lodish et al., Molecular Cell Biology, 9e, © 2021 W. H. Freeman and Company31

Answered: 1 MSH2 MSH6 Template strand 5' A 3'…

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Describe how the mismatch excision-repair pathway corrects errors introduced during replication. The following steps can be used for description of this process: Step 1: Damage recognition; Step 2: Unwinding and excision; and Step 3: Gap repair by D N A polymerase and ligase.

1
MSH2
MSH6
Template strand
5'
A
3'
Newly synthesized
daughter strand
MLH1 endonuclease,
PMS2
2
DNA helicase
DNA exonuclease
5'
3'
5'
3'
Gap repair by DNA
polymerase and ligase
3
5'
3'
A
|IT|||
3'
5'
31
Lodish et al., Molecular Cell Biology, 9e, © 2021 W. H. Freeman and Company
31

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