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1) During anaphase, Kinesin-13 proteins are localized at the kinetochore (A1) and the spindle pole (A2). While many kinesins can bind onto straight protofilaments and "walk" along the microtubule, studies have shown that the high-affinity binding site for Kinesin-13 family members is only on a curved protofilament. What is the significance of this? Why would Kinesin-13 only bind strongly with curved protofilaments? 2) What is the role of Kinesin-5 during anaphase (B1)? What would occur if kinesin- 5 "walked" towards the negative ends of the microtubules? 3) Astral microtubules (B2) aid in spindle orientation and position, a role facilitated by the association of dynein light chains (their tail) to the cell membrane. Explain the purpose of this association with the membrane, and how it may assist in cytokinesis.

1) During anaphase, Kinesin-13 proteins are localized at the kinetochore (A1) and the spindle pole (A2). While many kinesins can bind onto straight protofilaments and "walk" along the microtubule, studies have shown that the high-affinity binding site for Kinesin-13 family members is only on a curved protofilament. What is the significance of this? Why would Kinesin-13 only bind strongly with curved protofilaments? 2) What is the role of Kinesin-5 during anaphase (B1)? What would occur if kinesin- 5 "walked" towards the negative ends of the microtubules? 3) Astral microtubules (B2) aid in spindle orientation and position, a role facilitated by the association of dynein light chains (their tail) to the cell membrane. Explain the purpose of this association with the membrane, and how it may assist in cytokinesis.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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1) During anaphase, Kinesin-13 proteins are localized at the kinetochore (A1) and the spindle pole (A2). While many kinesins can bind onto straight protofilaments and "walk" along the microtubule, studies have shown that the high-affinity binding site for Kinesin-13 family members is only on a curved protofilament. What is the significance of this? Why would Kinesin-13 only bind strongly with curved protofilaments? 2) What is the role of Kinesin-5 during anaphase (B1)? What would occur if kinesin- 5 "walked" towards the negative ends of the microtubules? 3) Astral microtubules (B2) aid in spindle orientation and position, a role facilitated by the association of dynein light chains (their tail) to the cell membrane. Explain the purpose of this association with the membrane, and how it may assist in cytokinesis.
Transcribed Image Text:1) During anaphase, Kinesin-13 proteins are localized at the kinetochore (A1) and the spindle pole (A2). While many kinesins can bind onto straight protofilaments and "walk" along the microtubule, studies have shown that the high-affinity binding site for Kinesin-13 family members is only on a curved protofilament. What is the significance of this? Why would Kinesin-13 only bind strongly with curved protofilaments? 2) What is the role of Kinesin-5 during anaphase (B1)? What would occur if kinesin- 5 "walked" towards the negative ends of the microtubules? 3) Astral microtubules (B2) aid in spindle orientation and position, a role facilitated by the association of dynein light chains (their tail) to the cell membrane. Explain the purpose of this association with the membrane, and how it may assist in cytokinesis.
Team Application Problem: Microtubules (-) (+) kinesin-5 Kinesin-13 B1 (-) A1 (+) dynein A2 Kinesin-13 000 B2
Transcribed Image Text:Team Application Problem: Microtubules (-) (+) kinesin-5 Kinesin-13 B1 (-) A1 (+) dynein A2 Kinesin-13 000 B2
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