. What physiological effect would you predict from a mutation thatreplaced with serine the cysteine in the constant part of theimmunoglobulin light chain that is involved in disulfide-bond for-mation with the heavy chain? ,

Immunoglobulin (Ig), is considered as the protein, which is produced by the immune cells such as…

Answered: . What physiological effect would you…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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(60). A 3 year old boy is evaluated because he had recurrent episodes of otitis media, an episode of pneumonia, and chronic diarrhea since he was 6 months of age.His height is in the 10th percentile and his weight is in the 8th percentile. Serum IgM concentration is increased and serum IgG, IgA and IgE concentrations are markedly decreased. Which of the following molecules is most likely deficient in this patient? (A) C1 inhibitor (B) C8 (C) CD 40 ligand (CD 154) (D) interleukin-2 (IL-2) receptor gamma chain (E) NADPH oxidas
What is the meaning of (Helf-life) for immunoglobulin ?such as the helf life for IgG is 23 day.!!???
NCR- ILC3 make up one of the most frequent ILC subsets in the human peripheral blood, while NCR+ ILC3 are virtually absent in the circulation during homeostasis. Importantly, the healthy human intestine hosts dominantly NCR+ILC3, which have been shown to be essential in maintaining gut homeostasis. The signature cytokine of NCR+ ILC3 is IL-22. ILC3 in mice sense their environment and control gut defense as part of a glial-ILC3-epithelial cell unit orchestrated by neurotrophic factors. Enteric ILC3 express the neuroregulatory receptor RET. ILC3-autonomous Ret ablation led to decreased innate interleukin-22 (IL-22), impaired epithelial reactivity, dysbiosis and increased susceptibility to bowel inflammation and infection. Does this this complex neuro immune cross talk in the intestine account for the NCR ILC3 cells producing IL-22 while no such associations exist in the circulation where the ILC3 cells are NCR- and produce IL-17? maybe O yes O no
The small fragments of some complement proteins initiate a local inflammatory response. Recent studies using mouse models of pulmonary inflammation (a model for human asthma) have found that mice deficient in the C3a receptor have greatly reduced disease symptoms when challenged with inhaled preparations containing extracts of the fungal pathogen Aspergillus fumigatus. Specifically, the C3a receptor-deficient mice showed reduced influx of granulocytes and lymphocytes into the lung and reduced fluid in the lung after challenge. What is the explanation for these findings?
135. During an experiment, a transgenic mouse is developed in which regulatory T lymphocytes (Tregs) are made more sensitive to Fas-mediated apoptosis. The enhanced apoptosis of Tregs will most likely cause an increase in which of the following in this mouse? A) Autoantibody production B) Basophil degranulation C) Complement activation D) Dendritic cell migration E) Neutrophil activation
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For an Immunoprecipitation experiment:The cellular extract contains a protein labeled with a fluorescent dye, which emits green fluorescence under UV light. Explain your observations in IP-1, IP-2, and IP-3 tubes by considering the interaction among antibody 1 (or antibody 3), the fluorescent-labeled protein, and the protein-A agarose beads.
The F ab fragment of an antibody molecule has essentially the same affinity for a monovalent hapten as does intact IgG. (a) What is the smallest unit of an antibody that can retain the specificity and binding affinity of the whole protein? (b) Design a compact single-chain protein that is likely to specifically bind antigen with high affinity.
Can a mouse infected with Bacillus anthracis generate antibodies against the S-layer? How do you know? I need help finding the answer in the article and explain in short answer link to article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC106848/
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. What physiological effect would you predict from a mutation that replaced with serine the cysteine in the constant part of the immunoglobulin light chain that is involved in disulfide-bond for- mation with the heavy chain? ,