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Type 2 Diabetes (T2DM)

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Type 2 diabetes (T2DM) is an world health problem due to high prevalence and mortality [1]. It is characterized by hyperglycemia caused by defects in insulin secretion and/or insulin action. DM is associated with many well-known chronic comorbidities and complications that compromise many tissues especially blood vessels, heart and nerves [2]. Dynamic cerebral autoregulation could be an early manifestation of microvascular disease in diabetes and could be present in absence of cardiovascular autonomic neuropathy [3]. During low to moderate intensity dynamic exercise, cerebral blood flow (CBF) and brain oxygenation show an increase as a function of exercise intensity of mild to moderate intensity with a parallel increase in cerebral metabolism …show more content…

In T2DM, the oxygen delivery is compromised by a limited cardiac output response [8] and they show reduced cerebral perfusion and oxygenation during incremental exercise compared with health people [9]. Systemic and cerebral vasculatures are affected due limitations in microcirculatory blood flow and impaired vasodilatory capacity [8]. In addition, impairments in regulation of the skeletal muscle vasculature have been reported both at rest and at exercise associated with exaggerated sympathetic vasoconstriction, endothelial dysfunction and attenuated metabolic vasodilatation in elderly [10-12] and T2DM …show more content…

Steiner et al [24] demonstrate that tissue oxygenation index derived of NIRS can evaluate cerebral blood flow velocity and this data can be used to provide indicer of dynamic cerebral autoregulation. Understanding if the T2DM affect frontal lobe deoxygenation together with pulmonary exchange during dynamic moderate exercise might provide new insights on the mechanisms for impaired exercise capacity related with the vascular dysfunction. Recently, Vianna et al [25] demonstrated impaired cerebrovascular autoregulation during high intensity isometric contractions. However, remains unclear how the cerebral autoregulation is impacted by T2DM during dynamic exercise. Moreover, to learn this new analysis in the Prof. Hughson laboratory will allow that in the future we use this method together with other measurements (arterial blood pressure, heart rate and peripheral muscle deoxygenation) that will improve the evaluation of the central and peripheral cardiovascular interactions in health and

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