Dyslipidemia is a pathological alteration of lipid and lipoprotein concentrations in the blood. It is one of the main elements of metabolic syndrome. Epidemiological studies have shown that persons with the metabolic syndrome have an increased risk of colorectal cancer (CRC). One of the possible mechanisms is that lipids and lipoproteins have been found to be associated with neoplastic processes as well as inflammation, insulin resistance and oxidative stress. On the other side, some of the factors that influence lipid and lipoprotein concentration unfavorably (ie. smoking, obesity, a high fat and low fiber diet consumption) can contribute to the development of colon cancer as well. The purpose of this study is to investigate the association between low HDL blood levels and colonic cancer.
Methods:
A retrospective case-control study was conducted. A chart review was performed on the charts of 183 patients who were diagnosed with colonic adenoma or carcinoma after having colonoscopy/sigmoidoscopy done in our hospital from 1/1/09 till 12/31/10. Information regarding demographics, HDL level, endoscopy and biopsy findings, site of the lesion and the period between endoscopy and the closest HDL measurement we have in our records.
Results:
Our study population included 183 patients (66 males and 116 females). 86 patients had adenomas while 96 patients were diagnosed with CRC. The mean age was 61.1+/- 11 years and 80 +/- 12.2 years for adenoma group and carcinoma group
High cholesterol is a dangerous disease that can lead to many life-threatening ailments, and can be lowered by eating healthy, while maintaining a balanced diet of leveled cholesterol. Cholesterol, the sleek-fat like substance that roams in the blood of a body. It is vital to life, but when there is too much intake of cholesterol, it can cause the body to malfunction and cause problems. There are two types of cholesterol HDL and LDL, which varies in the amount of protein and cholesterol it holds Too much cholesterol in a body is dangerous, and surprisingly, has no symptoms. The two main types of cholesterol are HDL and LDL, HDL helps reduce the chances of chronic heart disease, whereas LDL is the main reason for plaque build-up in artery
The aim of this study revealed an interested trend when comparing IL-6 results to the different metabolic diseases listed as top Ten Global Health Disparities. This study showed that CR will benefit situations where there is a socioeconomic disadvantage, even factor that include health disparities among race and age would show benefit because CR is suitable for all disadvantage groups. Caloric Restriction (CR) has proven to be non-expensive, beneficial agent against age related, racial, and socioeconomic disadvantage, associated with health disparities. The results for IL-6 in each case indicated that CR could improve endothelial function in rats with different metabolic diseases possibly through reduction in body weights resulting in reduction in fat mass and concomitant reduction in the production of the proinflammatory cytokines. IL-6 is expected to be reduced in Colorectal cancer (CRC) rats under
The researched statistic would show how quantitative evidences support the ideas of unhealthy food and sporadic cancer. It would be helpful to provide information contrasting hereditary cancer and sporadic cancer, as well as narrowing down the topic to specific
What is Mr. Watt’s risk factors related to colon cancer? Consider all aspects of his health, his family history and his culture.
Some symptoms of RCC are lower back pains, lumps, anemia, fatigue, fever, weight loss, and other symptoms are unusual hair growth in women, vision problems, pale skin, and swelling of the veins around one or both testicles. The treatment for stage one RCC is surgery, radiation therapy, arterial embolization, and a clinical trial. Stage 2, surgery, surgery before of after radiation therapy, radiation therapy, arterial embolization and a clinical trial. Stage 3, surgery , arterial embolization, radiation therapy, surgery, and a clinical trial of biologic therapy following surgery. Stage 5 and recurrent renal cell cancer surgery, surgery to reduce the size of the tumor. Targeted therapy, biologic therapy, radiation therapy as palliative therapy to relieve symptoms and improve the quality of life and a clinical trial of new treatment. Renal cell cancer is a cancer that has come back after it was treated. The cancer can come back many years after its has been treated correctly, in the kidney or in other parts of the body. The causes of RCC are your age, the older you are the greater risk you have, your gender, males are most likely to develop RCC. Your genes, your family history, you smoking, you being overweight, and you having high blood pressure. All of those things can cause you to have
Colonoscopies are the most common way to detect colon cancer. Therefor doctors recommend regular screening tests every 10 years, but people with higher risk, such as a family history with the disease or old age may need to go in more frequently. Normally people should begin screenings at age 50 but people with an increased risk or signs of symptoms, should talk to their doctor about the best plan. Consequently, most people don’t think they need to go in because they don’t show any symptoms, it's money for something they probably don’t even have, or they think since no one else in their family has had it, their safe, but they're actually excuses for something that could help save you from the grueling pains of colon cancer. For those of you, I urge you to be vigilant about possibilities. No matter what your age. It can be fought before it even begins!
In our cohorts we prospectively recruited patients with HCC presented at MD Anderson Cancer Center (MDACC) from January 2000-May 2008 and used as a training cohort. Then, we enrolled patients from the same institution from June 2008-January 2011 and used as the first independent prospective validation cohort and also from different institution, Assiut University Hospital, Egypt from April 2012- September 2013 as the second independent prospective validation cohort. This study was approved by the two institutional Review Boards. Written informed consent for participation was obtained from each study participant. We recruited all patients diagnosed with HCC either pathologically or radiologically confirmed. For the three HCC cohorts, the study involved pathologically or radiologically confirmed HCC; the diagnosis was based
A total of 15,296 patients diagnosed with primary HCC met the study criteria. Majority of the patients were men (74.47%) and belonged to the Caucacian race (58.57%). Median age at the time of diagnosis was 66.16 years (range: 42.33 - 95.5 years). Detailed patient demographics are presented in Table 1. The median follow-up duration was 28 months (range: 6 - 18.5 years). A total of 446 (2.83%) patients developed 466 SPM with observed/expected (O/E) ratio of 1.07 (95% CI= 0.97-1.17) and AER of 7.17 per 10,000 population, p = 0.16. These patients had significant excess risk of non-Hodgkin’s lymphoma and several solid tumors including cancers of head and neck, lung, thyroid, adrenal glands, stomach, anus and hepatobiliary region. Interestingly, there was significantly decreased risk of prostate cancer among HCC patients compared to general population.
The majority of the studies done on the link between diet and cancer indicate that there is a relationship between high fat intake and an increased risk
In this essay I will be discussing the current recommendations for large bowel screening, to diagnose bowel cancer, including those categorised as high risk. I will also be discussing the role of imaging in the initial diagnosis and the subsequent follow up.
In most cases of colon cancer begin a small tumor from non-tumor (benign), called Noah Water Police (adenomatous Polyps). Time Police tumors (Polyps) these will become a colorectal cancer tumors. Tumor is relatively small and can mild symptoms. For this reason, and to provide recommendations to doctors to do a colonoscopy to find tumors police on a regular basis to help prevent colon cancer tumor police before it becomes cancerous tumors in the colon.
R.T. is a 64-year-old man who comes to his primary care provider’s (PCP’s) office for a yearly examination. He initially reports having no new health problems; however, on further questioning, he admits to having developed some fatigue, abdominal bloating, and intermittent constipation. His nurse practitioner completes the examination, which includes a normal rectal exam with a stool positive for guaiac. Diagnostic studies include a CBC with differential, chem 14, and carcinoembryonic antigen (CEA). R.T. has not had a recent colonoscopy and is referred to a gastroenterologist for this procedure. A 5-cm mass found in the sigmoid colon confirms a diagnosis of adenocarcinoma of the colon. A referral is made for
Research conducted by Levi et al. (2011) in a prospective cohort study on Jewish Israeli males aged between 16 & 19 years concluded that adolescents with a BMI classified as OW/OB had a 53% increased risk of developing colon cancer with HR of 1.53; 95% CI, 1.17-2.0 (statistically significant result). However, it was shown that those adolescents with increased BMI had no increased risk of developing rectal cancer with HR of 1.09; 95% CI, 0.68-1.73 (statistically insignificant).
The Ministry of Health has contributed almost $40 million dollars, over the past four years, towards the development and implementation of the National Bowel Screening Programme (Ministry of Health [MOH], 2016a). The aim of this is to develop a programme to regularly screen people who are considered a ‘high risk’ for developing colorectal cancer. People considered to be at a high risk for developing colorectal cancer are those of advancing age (60+), previous colonic polyps, a diabetes diagnosis, and those who have a previous family history of colorectal cancer (Brenner, Zwink, Ludwig & Hoffmeister, 2017, p.95; Dallas, 2017; Engelke, 2016).
There are five ways that we can do to prevent colorectal cancer in our daily life. First, maintaining a healthy weight. There are at least 11 different cancer have been linked to weight gain and obesity. (siteman.wustl.edu) Second, do not smoke. Smoking can increase your chances to get cancer in addition to heart disease stroke and emphysema. (siteman.wustl.edu) Third, do more exercises. Being physically active lowers the risk of many serious diseases, including colon cancer. (siteman.wustl.edu) Forth, limit red meat or processed food. Eating steak or pork and bacon or sausage can increased the risk of colorectal cancer. (siteman.wustl.edu)Last but not least, get enough calcium and vitamin D. According to statistic, people who did not get enough vitamin D and calcium has a higher risk of colorectal cancer. (siteman.wustl.edu)