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The Association Between Low Hdl Blood Levels And Colonic Cancer

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Dyslipidemia is a pathological alteration of lipid and lipoprotein concentrations in the blood. It is one of the main elements of metabolic syndrome. Epidemiological studies have shown that persons with the metabolic syndrome have an increased risk of colorectal cancer (CRC). One of the possible mechanisms is that lipids and lipoproteins have been found to be associated with neoplastic processes as well as inflammation, insulin resistance and oxidative stress. On the other side, some of the factors that influence lipid and lipoprotein concentration unfavorably (ie. smoking, obesity, a high fat and low fiber diet consumption) can contribute to the development of colon cancer as well. The purpose of this study is to investigate the association between low HDL blood levels and colonic cancer.
Methods:
A retrospective case-control study was conducted. A chart review was performed on the charts of 183 patients who were diagnosed with colonic adenoma or carcinoma after having colonoscopy/sigmoidoscopy done in our hospital from 1/1/09 till 12/31/10. Information regarding demographics, HDL level, endoscopy and biopsy findings, site of the lesion and the period between endoscopy and the closest HDL measurement we have in our records.
Results:
Our study population included 183 patients (66 males and 116 females). 86 patients had adenomas while 96 patients were diagnosed with CRC. The mean age was 61.1+/- 11 years and 80 +/- 12.2 years for adenoma group and carcinoma group

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