The SEER is a population-based cancer database by National Cancer Institute. The SEER 13 represents approximately 14% of the population of the United States and includes 13 cancer registries - San Francisco-Oakland, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle (Puget Sound region), Utah, Atlanta, San Jose-Monterey, Los Angles, Alaska Natives, and rural Georgia. High quality data are collected from hospitals and cancer treatment centers. The database includes primary tumor site, staging, patient demographics, treatment modality and survival statistics (10). We selected adult patients (≥ 18 years) diagnosed with first primary HCC between January 1992 and December 2011. We excluded cases diagnosed at autopsy and those lost to …show more content…
Results:
A total of 15,296 patients diagnosed with primary HCC met the study criteria. Majority of the patients were men (74.47%) and belonged to the Caucacian race (58.57%). Median age at the time of diagnosis was 66.16 years (range: 42.33 - 95.5 years). Detailed patient demographics are presented in Table 1. The median follow-up duration was 28 months (range: 6 - 18.5 years). A total of 446 (2.83%) patients developed 466 SPM with observed/expected (O/E) ratio of 1.07 (95% CI= 0.97-1.17) and AER of 7.17 per 10,000 population, p = 0.16. These patients had significant excess risk of non-Hodgkin’s lymphoma and several solid tumors including cancers of head and neck, lung, thyroid, adrenal glands, stomach, anus and hepatobiliary region. Interestingly, there was significantly decreased risk of prostate cancer among HCC patients compared to general population.
Younger patients (aged <60 years) had increased risk of malignancies of oropharynx (O/E ratio of 4.18, CI = 2.23 - 7.15, p=.01; AER 7.15), lung and bronchus (O/E ratio of 3.03, CI=1.9 - 4.58, p= 0.01; AER 11.6), hepatobiliary system (O/E ratio 4.35, CI=2.32-7.44, p=.01; AER 7.8), small intestine (O/E ratio of 8.11, CI=1.67-23.1, p=.01; AER 2.07), non-Hodgkin’s lymphoma (O/E ratio of 4.44, CI 2.43-7.44, p=.01; AER 8.53.) Among older patients (Age ≥ 60 years), there was increased risk of cancers of oropharynx (O/E ratio 1.7, CI
The National Cancer Moonshot is the Obama Administration’s initiative to facilitate the progress of cancer research. Announced during the 2016 State of the Union, the Moonshot is being headed by Vice President Joe Biden with the goal of doubling the rate of scientific advancement over the next five years. At the moment, the progress is largely organizational and informative as the Vice President hopes to connect large swathes of the scientific community. A final Moonshot report is due at the end of the year, but action is expected to increase dramatically this fall.
In recent years, treatment options for advanced solid tumors have significantly advanced.1,2 Patients now routinely have their tumors genotyped in order to identify genomic markers that can allow their treatment to be personalized with targeted therapies that are less toxic and more effective. Prior studies have found that up to 64% of patients have these oncogenic drivers, and patients with these drivers in their tumors live longer when they are treated with targeted therapy.1 The Profile project was launched at Dana-Farber Cancer Institute and Brigham and Women’s Hospital in 2011 as the platform for Precision Medicine. Profile provides detailed testing on tissue samples obtained during the course of clinical care for a panel of genetic
For our analysis, we used cohort data from the Surveillance, Epidemiology, and End Results (SEER9) Program of the National Cancer Institute with data spanning from 1973-2012. The SEER database collects cancer surveillance data from population-based cancer registries in the United States with an approximate coverage of 30% of the entire US population. This data is de-identified and publicly available data and therefore did not require the approval of an institutional review board.
Meghan is a 20-year-old female here today to establish care. She recently relocated to this area with her family after moving away and living in New Jersey for two years. She would like to talk about her birth control pill.
Discussion The primary purpose of this review is to determine how cancer registries provide and evaluate data quality to ensure more accurate and effective in diagnosing and improving cancer treatment. Cancer registration data is an underdeveloped topic within the medical field and does not have the proper amount of research to accurately determine if the data is organized and effective. This topic could lead to more data being processed for cancer patients, increasing their chance of being diagnosed and treated within a reasonable timeframe. In order to accomplish this task, sources were found to further explore the data that has been published on this topic.
The SEER 13 is a population based cancer database sponsored by National Cancer Institute. SEER 13 represents 13.8% of US population and covers following geographical areas - San Francisco-Oakland SMSA, Connecticut, Detroit (Metropolitan), Hawaii, Iowa, New Mexico, Seattle (Puget Sound), Utah, Atlanta (Metropolitan), San Jose-Monterey, Los Angeles, Alaska Natives, and Rural Georgia. The SEER program collects comprehensive cancer data from hospitals and cancer treatment centers and
We retrospectively analyzed the treatment charts of patients of HNSCC treated at our institute from 2006 to 2014. A total of 5000 cases were registered during this period. Patients of head and neck squamous cell carcinomas (Oral cavity, Oropharynx, Hypopharynx, Larynx) under the age of 20 years were taken up for analysis.
It also appears that both male and females living in the Love Canal tract within the 65-75 year old group had the highest rates of age-specific respiratory cancer (Males: SIR:1.7, 5%CL8-23 and Females: SIR:2.0, 5%CL: 1 to 8). However, no other age groups in this track had similar results. Overall, this study suggested there were not consistently elevated rates of the studied cancers within the Love Canal population (Janerich et al.,
Africa, where it is one of the most common cancers [1].With the highest prevalence in
when compared to the thousands of people in the United States but the number of 1,960 is not
Brandon Stanton, the mind behind Humans of New York, has taken a couple weeks off from shooting in the streets of New York City to take photos and gather stories within the Pediatrics Department of the Memorial Sloan Kettering Center in New York City.
Cancer Registries (NPCR) collect data on cancer occurrence and the type of initial treatment (CDC, 2013). This can include the type, extent, and location of the cancer. The registries collects information about cancer patients and the treatments they receive and then stores it in a computer (CDC, 2013). According to the CDC website, the purpose of cancer registries is to monitor cancer trends over time, show cancer patterns in various populations and identify high-risk groups (2013). The registries also guides planning and evaluation of cancer control programs. The registry helps set priorities for allocating health resources. The registries help advance clinical, epidemiologic, and health services research on different
The Centers for Disease Control and Prevention (CDC) (2013) defines cancer clusters as a larger than anticipated amount of similar cancer cases arising at a given time among members of a defined community. Cancer clusters present many challenges due to the complexity of the analytic process and the abundance of inquiries and concerns. Because the research and studies of cancer clusters in the United States have uncovered few conclusive determinants, many states are hesitant in dedicating excess resources and money to the meticulous processes. Seeing the issue of discovering potential environmental hazards as a priority, Maryland is employing a specifically appointed workgroup to process all community concerns to enforce serious
Respiratory cancer pertains to any cancer that affects any part of the respiratory system such as the lungs, trachea, larynx, and bronchus (U.S. Respiratory Cancer, 2014). Symptoms of each type vary and depend on the location of the cancer. Some symptoms of lung cancer and cancer of the bronchus include a cough, chest pain, and coughing up blood. Likewise some characteristics in cancer of the larynx are hoarseness, voice changes, sore throat, and feeling of a lump in the throat (Public Health, 2015). These three are the most common forms of respiratory cancer. However, out of those three forms Lung and Bronchus cancer has a significantly higher amount of deaths and cases in comparison to Laryngeal cancer. In 2013, it was estimated there were 163,890 respiratory system related deaths for both sexes. In comparison to other cancers, it accounted for the highest amount of estimated deaths even though it 's estimated new cases were not the highest (see fig.1). In this paper I will specifically discuss Laryngeal cancer, its cell type/location, incidence/prognosis, screening, diagnosis, treatment, risk factors/prevention, and current research on Laryngeal cancer.
In 2012, an estimated 156,877 new cases of laryngeal cancer were diagnosed worldwide. In the same year, this cancer was responsible for 83,376 deaths worldwide[1]. Surgical resection followed by chemotherapy remains to be the standard treatment for laryngeal carcinoma[2]. However, postoperative malfunction or completely loss of phonation may cause great pathological and psychological disorder to patients who may then loss their social adaptability. Moreover, a considerable number of patients are threatened by the risk of local recurrence and metastasis. Chemotherapy is advantageous in reserving laryngeal function and structure[3]. However, multidrug