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Teloomerase Research Paper

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Telomerase (TERT) is an enzyme responsible for maintaining the ends of telomeres and reversing the process of telomere shortening in humans by adding a “TTAGGG” polynucleotide to the 3’ end of the telomere. The addition of the “TTAGGG” compensates for inefficiencies in replication of the ends of DNA in eukaryotes. Telomerase is limited to highly proliferative cells such as germ cells and lymphocytes where the telomerase is necessary to maintain telomere length, and the telomeres themselves are not sufficiently long to facilitate such rapid cell division without incurring damage to the DNA. Most somatic cells exhibit no telomerase activity and in cells where telomerase is present telomerase activity is strictly regulated. In cells that exhibit

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