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Systematic Research Studies

Decent Essays

The purpose of a systematic review is to find the most pertinent research available on a specific topic. This is done by combining the results from multiple studies. A systematic review summarizes all of these results of controlled trials and provides a high level of evidence on the effectiveness. Conclusions may be made about the evidence and recommendations may be given for healthcare based on the finding. This paper will evaluate systematic research reviews related to children vaccinated with the Measles, Mumps, and Rubella Vaccine (MMR), the relevance of the research problem, research rigor, and clarity of the findings in the SRR, overall findings and implications for its use as an advanced practice nurse.
Relevance of the Research Problem …show more content…

(2012) For this research study the author searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011, Issue 2), which includes the Cochrane Acute Respiratory Infections Group's Specialized Register, PubMed (July 2004 to May week 2, 2011) and Embase.com (July 2004 to May 2011). Using a comparative prospective or retrospective trials assessing the effects of the MMR vaccine compared to placebo, do nothing or a combination of measles, mumps and rubella antigens on healthy individuals up to 15 years of age. Two review authors independently extracted data and assessed methodological quality of the included studies. One review author arbitrated in case of disagreement. The study included five randomized controlled trials (RCTs), one controlled clinical trial (CCT), 27 cohort studies, 17 case-control studies, five time-series trials, one case cross-over trial, two ecological studies, six self-controlled case series studies involving in all about 14,700,000 children and assessing effectiveness and safety of MMR vaccine. Based on the available evidence, one MMR vaccine dose is at least 95% effective in preventing clinical measles and 92% effective in preventing secondary cases among household contacts.
This study used a meta-analysis; meta-analysis combines a number of different studies which are directed by several separate researchers to quantify the effects a given approach has on a specific outcome. By extending the data pool to include various different situations and increasing sample sizes the results produce a better quantitative estimate. Therefore there is a Level I of evidence for this research project. This is the strongest level of evidence because it uses already proven research to further expand the research

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