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Summary: The Most Common Cardiac Disease

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It is one of the most common cardiac disorder and mostly causes sudden death in children and adolescents .the pathology of it consist of left ventricular hypertrophy , a thickened ventricular septum, atrial enlargement and small left ventricular cavity . The variability is seen between the phenotype and the cardiomyopathies due to different function performed by sarcomeric proteins. One such example is the mutation in the gene that encodes B- myosin heavy chain was the first mutation identified as a cause of familial hypertrophy cardiomyopathy .the clinical change varies from person to person for ex- an arginine to glutamine substitution at position 403 and an arginine to tryptophan t position 719 causes sudden heart

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