It is one of the most common cardiac disorder and mostly causes sudden death in children and adolescents .the pathology of it consist of left ventricular hypertrophy , a thickened ventricular septum, atrial enlargement and small left ventricular cavity . The variability is seen between the phenotype and the cardiomyopathies due to different function performed by sarcomeric proteins. One such example is the mutation in the gene that encodes B- myosin heavy chain was the first mutation identified as a cause of familial hypertrophy cardiomyopathy .the clinical change varies from person to person for ex- an arginine to glutamine substitution at position 403 and an arginine to tryptophan t position 719 causes sudden heart
This is weakness in the muscle of the heart not attributable to any extrinsic cause. Actually, most intrinsic Cardiomyopathy can be traced back to some sort
Hypertrophic cardiomyopathy is an inherited autosomal-dominant pattern affecting nearly 1 in 500 people, affecting both men and women equally. Which makes it the most “common genetic heart disease in the United States” [5] Many studies have been done on the causes of this disease. Research has shown the mutations of between 10 to 13 sarcomeric proteins are associated with HCM. Each mutated gene has a different pathological characteristic.
This condition is usually caused by abnormal genes that control heart muscle growth. These abnormal genes are passed down through families (inherited).
Familial Cardiomyopathies (FC) are a collection of cardiac diseases that vary vastly genetically, and pathologically (1, 2). Hypertrophic cardiomyopathy (HCM) is the most common form of FC (2). HCM is diagnosed often with left ventricular hypertrophy without a noticeable increase in external load and smaller ventricular cavity, but with a preserved ejection fraction (3). That is, the percent of blood leaving the left ventricle (5) does not change. Other pathologies include interstitial fibrosis, thickening of the media in intramural arteries, and myocytes disarray greater than 5%; which is a hallmark of HCM (4). HCM shows variability in its penetrance, from a patient with no symptoms, to having sudden cardiac death (SCD)
Through more research, dilated cardiomyopathy has been found to have a genetic component (MacRae, 2010). Though there have been families who have volunteered to be screened, there are still some 40 chromosomal loci and potential disease genes discovered so far. The reason for the wide range of variants of potential loci is due to how prevalent the disease is in families. For example, the more individuals who have been diagnosed with the disease, researchers were then able to find similar loci among the affected; whereas, the families who had fewer affected individuals laid a wider range of
Aging brings many behavioral, physiological and psychological changes in human. As many older adults surpass young adults they experience deterioration in cognitive abilities such as memory loss, inability to perceive, reason, and understand as they age. In human brain, capacity is involved in person’s ability to understand and interpret the information presented to them. According to the text book Adult Development and Aging: Biopsychosocial perspective Canadian edition (2015), capacity is referred to as a context-dependent and fluid because, a person may lack capacity for making complicated decision, but they still may have a capacity to outperform simple decisions and their cognitive abilities may diminish as they age (Whitbourne, Whitbourne, & Konnert, 2015, p. 62). In the construct of capacity for any research project, a researcher must receive an informed consent in order to
Hypertrophic Cardiomyopathy is a genetic disorder that causes progressive abnormal thickening of the heart (1). This thickening of the muscle of the heart may be minor, slowly progressing or severe producing sudden death. People with Hypertrophic Cardiomyopathy have a large thick heart muscle, and as a result decreases the cavity size of the heart. This means the heart holds and pumps less blood. It also can make it harder for the heart to relax and fill with blood. (2) It is an obstruction to the flow of blood as it is pumped out of the heart. Once the muscle is too large, it’s function decreases and the heart starts to quiver in
For my proposal, I would like to start by presenting a Heart Disease Quiz to see if people are aware or have knowledge about Heart disease. This will allow those to understand why Heart Disease is a serious and very dangerous disease and it is essential to understand and how to protect our children from this treacherous disease.
Coronary heart disease (CHD), also known as ischemic heart disease is the most prevalent form of cardiovascular disease in Australia. While over 20,000 of deaths in 2011 were attributed to CHD, there were estimated 590,000 Australians 18 years old and above diagnosed with CHD in 2011-2012 (AIHWAustralian Institute of Health and Welfare, 2014; Craft, 2014, p. 596).
The book “Heart Disease” is very intriguing but, very boring at the same time. In this book, the main topic is Heart Disease. It talks about how Heart Disease causes lot of deaths in USA which is interesting because, I thought there were more deaths in the USA caused by guns. In the first chapter it explains what Heart Disease is and what it is about. The book also describes symptoms and diagnostics which explains some of the side effects of having Heart Disease. The book also describes how you can treat the disease and it gives you information on some alternate treatments that can also resolve and minimize heart disease like exercising.
Heart diseases also known as cardiovascular diseases are various conditions types that may interfere with the function of the heart. These condition types include atherosclerotic also known as coronary artery heart disease which is shown to affect arteries leading to the heart, the heart valve disease which affects the functionality of valves in regulating in and out of the blood flow to the heart. Cardiomyopathy affects the squeezing of the heart muscles. Arrhythmias also called the heart rhythm disturbances affects the electrical conductions. There are also heart infections which are resulted by structural problems of the heart which usually develops before birth. (Wedro)
The prevalence of ischemic heart disease is increasing in the United States, and around the world. Sudden cardiac arrest, the primary cause of death related to ischemic heart disease, is now the leading cause of death worldwide (Weng & Sun, 2012). Of the more than 300,000 patients who suffer sudden cardiac arrest in the United States each year, only 7.9% survive to hospital discharge (Weng & Sun, 2012). Lilja, et al. (2015) report that despite recent improvements in methods of cardiac resuscitation, severe and often permanent brain injury remains the leading cause of death in hospitalized patients post-resuscitation. Recent research has sought to preserve neurologic function and improve outcomes post-resuscitation through the implementation of therapeutic hypothermia. Neumar, et al. (2015) provide a 2015 update to The American Heart Association’s Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care recommending that Targeted Temperature Management (TTM) between 32°C and 36°C be initiated and maintained for at least 24 hours in all comatose adult patients following restoration of spontaneous circulation (ROSC) after cardiac arrest (p. S343).
Heart disease is the number 1 killer in the United States of America. It’s important to have a heart protection strategy, especially as you get older. It should include exercise and a healthy diet, plus supplements for heart health as needed. Know your cholesterol, blood pressure and ideal weight. Lower risk factors and prevent early disability, illness or even death from heart disease. And although you can't help heredity, you can certainly be aware of any risk factors that may have been passed down through your family tree. After following the steps in this assignments all of the supplements I would recommend along with the information I have given you here are proven to help in preventing heart health. Most can be safely taken in combination.
A growing sense of concern about violence in communities across America has prompted many people to step back and evaluate the causes of this violence. Although there seem to be many contributing factors, one that is repeatedly highlighted is the depiction of violence in the media. A substantial amount of research has been done on certain forms of media, especially television and video games, while other forms have been almost completely neglected. In this paper, I will attempt to extend the implications of this research to theater, which has a long history of simulating violence. This is an important connection to investigate, as theaters still draw an impressive number of patrons and play an important role in the economy. In order for theater companies to make informed decisions about what plays to put on, and for parents to make wise decisions about what shows their children should attend, it is necessary to understand the complex relationship between simulated violence and mental health.
First day of 7th grade was amazing! Final period came and it was computer class. We would just sit on the computers and learn how to type fast. Once I finished I would play online games while everyone else got into groups. I sat alone because I had recently transferred to a new school due to moving to a new house. My first day of school finished and I had no clue how to get home, I had to remember what my grandma told me and just trust my gut. Walking home wasn't so bad but I took the longest way home. There was a group of girls I thought seemed nice so I followed them. They noticed me as the new kid and asked me to come join the walk home.