Sickle Cell Disease And Cancer

The only way you get sickle cell is by inheritance from a family member, whether it be your mom or your dad. If a person inherits the sickle cell gene from only one parent will not develop the gene but will have something called sickle cell trait. People with sickle cell trait do not have the disease, but they might have a few sickle cell blood cells in their bodies. Although having sickle cell trait does not give them the disease they have the sickle cell gene and it will be passed down to their kids. Kids and parents may never know for a fact if they have the gene or not that is why doctors recommend getting checked out for sickle cell genes. To check for sickle cell genes doctors use a special blood test called a hemoglobin electrophoresis. All newborns get screened and tested for sickle disease. It is required in every state to have your newborn tested for sickle cell

In order to get Sickle Cell Anemia, you must have the Sickle Cell Trait. This is defined as "A person who carries one sickle hemoglobin producing gene inherited from their parents and one normal hemoglobin gene." (3) People who only have one copy of the mutation have the trait. "It is estimated that 1 in 12 African Americans has sickle cell trait." (3) Having the trait will NOT cause SCD. However, having the gene does allow you to pass the mutation on to your children. In fact, "A child conceived by two people with sickle cell trait has one chance in two of also having sickle cell trait, one chance in four of having sickle cell anemia."(3)

Sickle Cell Anaemia is a heredity disorder in which the red blood cells are affected by altering into a mutated-form of haemoglobin, most commonly at low oxygen levels. The altered-form of haemoglobin are crescent-shape; which are not flexible and can easily block the blood flow in smaller blood vessels and arteries (refer to figure 1). When both alleles inherited carry the sickle cell anaemia disease; 100% of the body’s haemoglobin will mutate into the sickle (crescent) shape. Sickle cell disease is the codominance of only one inherited sickled allele, in which; the carrier can pass the disorder but does not express any significant symptoms or the anaemia itself. Sickle cell anaemia is an autosomal recessive disorder, thus both alleles must

In order to find out if a person has Sickle-Cell Anemia, doctors need to diagnose him/her using special methods. One simple, inexpensive method, which happens to be the most common one, includes giving the blood test called hemoglobin electrophoresis. It shows the hemoglobin type in person’s body. This blood test is now given in more than forty states, and is mostly performed on newborn babies. These tests also tell whether or not the child carries the Sickle-Cell trait. In addition, another method of diagnosis is called the Sickle-Cell solubility test. This test can possibly detect the presence of “bad” hemoglobin.

Sickle cell anemia (SCA) is an autosomal recessive genetic disorder. This missense mutation is characterized by mutant beta globin subunits that tend to stick together (Cummings, 2014). As a result, abnormally shaped red blood cells are produced by this disorder. The erythrocytes are sickle or crescent shaped. Sickling occurs under hypoxic conditions, in which there is insufficient supply of oxygen delivered throughout the body (Sun & Xia, 2013). In order to inherit this monogenic disease, one copy of the sickle globin gene from each parent must be passed on to the offspring (Ashley-Koch,

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Sickle cell anemia (SCA) is an inherited blood disease which causes normal, round, healthy red blood cells to transform into sickle-shaped cells. Normal red blood cells are flexible and can easily pass through capillaries to bring oxygen to different parts of the body. However, sickle cells are fragile, and can easily die, leading to anemia (red blood cell deficiency). SCA can also cause blood vessel occlusion (blockage of blood vessels), tissue infarctions (death due to lack of oxygen), bone, joint, and abdominal pain, yellow eyes and skin, pale skin, delayed growth, increased risk of infections, and damage to organs. The disease is passed on by autosomal recessive inheritance, which means both parents of a child must have the defective gene for the child to be affected. If only one gene is inherited, the victim becomes a carrier of the sickle cell trait, producing only some sickle cells with little or no symptoms. This means two people with the trait have a 25% chance of having a baby with sickle cell disease, 25% chance of them having no defects, and 50% chance of the baby becoming a carrier as well. When the gene is inherited, it mutates the beta (β) globin gene in chromosome 11, changing the hemoglobins produced using instructions from the gene from a healthy hemoglobin A (Hb A) to a mutated hemoglobin S (Hb S). Many tests can be done to check for sickle cell disease, the most common being an ordinary blood test, where the blood is examined for hemoglobin S. If the

Then I'll note that the cause of these symptoms varies depending on the type of sickle cell disease. so There is different types of anemia and each type have a causes . This is some of them: Iron deficiency anemia this type occurs because of iron deficiency in the body. as the bone marrow needs iron to produce hemoglobin because it can not produce it when there is not enough iron, it can not produce enough red blood cells . Aplastic anemia This is a rare type that occurs due to infections, autoimmune diseases and exposure to toxic chemicals. Sickle cell anemia this is hereditary, where the body

The disorders for Sickle Cell Anemia is mutation, autosomal recessive, and blood loss. The chromosomes traveled from one parent to another which mean it's a positive chance the child will have that disease. Also that

In fact there is a vast number of different Sickle Cell disease. The most recognized types of Sickle Cell Disease are Hemoglobin SS Disease, Hemoglobin SC Disease, Hemoglobin SB+ Thalassemia, and Beta-Zero Thalassemia. Hemoglobin SS Disease also known as Sickle Cell Anemia is the most common form of Sickle Cell Disease. Sickle Cell Anemia occurs when the patient inherits two genes that are abnormal and causes the shape of the red blood cell to alter. Hemoglobin SC disease is known as a Hemoglobinopathy. Hemoglobinapathy is a hereditary condition involving the abnormal form of hemoglobin. Hemoglobin SB+ Thalassemia is said to be a variant form of Sickle Cell Anemia. The final common form of Sickle Cell is Beta-Zero Thalassemia. Beta-Zero Thalassemia like Hemoglobin SB+ Thalassemia is similar to Sickle Cell Anemia. These different types of Sickle Cell vary from the type of symptoms and the different types of

Sickle cell anemia is a disease you get from having two sickle hemoglobin within your red blood cells. There’s no other way to develop this disease than by genetics, which only occurs if both of your inherited cells are abnormal. Unfortunately, since sickle cell anemia is an inherited disease, there’s no way to prevent

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Like most genes, hemoglobin genes are inherited in two sets…one from each parent(Ex. If one parent has Sickle Cell Anemia and the other is Normal, all of the children will have sickle cell trait. 4 If one parent has sickle cell anemia and the other has sickle cell trait, there is a 50% chance (or 1 out of 2) of having a baby with either sickle cell disease or sickle cell trait with each pregnancy,When both parents have sickle cell trait, they have a 25% chance (1 of 4) of having a baby with sickle cell disease with each pregnancy). HOW DO YOU KNOW IF YOU HAVE THIS TRAIT A SIMPLE PAINLESS BLOOD TEST followed by a laboratory technique called Hemoglobin Electrophoresis will determine the type of hemoglobin you have.

Sickle Cell Disease is an autosomal recessive genetic disease that occurs due to a mutation in the β-globin gene of hemoglobin. Autosomal meaning that it is not linked to a sex chromosome, so either parent can pass on the gene to their child. This mutation is a result of a single substitution of amino acids, Glutamic for Valine at position 6 of a β globin chain. The presence of this mutation causes

This disease is a genetic disease and it is hereditary. It is inherited as an autosomal recessive disease. This means that in order to get the gene you must receive a recessive trait from your mother and your father. The parents could both be heterozygous for the trait and therefore not have the disease, but instead they would both be a carrier. There are only a few ways that the parents could possibly pass the trait. One possibility of having a child with sickle-cell disease is if both parents are heterozygous and they both pass on their recessive allele, (25% chance for offspring to have sickle-cell disease). Another possibility