A Study On Sickle Cell Disease

Sickle cell anemia occurs when a person inherits two abnormal genes (one from each parent) that cause their red blood cells to change shape. Instead of being flexible and round, these cells are more rigid and curved in the shape of the farm tool known as a sickle - that's where the disease gets its name. The shape

The only way you get sickle cell is by inheritance from a family member, whether it be your mom or your dad. If a person inherits the sickle cell gene from only one parent will not develop the gene but will have something called sickle cell trait. People with sickle cell trait do not have the disease, but they might have a few sickle cell blood cells in their bodies. Although having sickle cell trait does not give them the disease they have the sickle cell gene and it will be passed down to their kids. Kids and parents may never know for a fact if they have the gene or not that is why doctors recommend getting checked out for sickle cell genes. To check for sickle cell genes doctors use a special blood test called a hemoglobin electrophoresis. All newborns get screened and tested for sickle disease. It is required in every state to have your newborn tested for sickle cell

CHIEF COMPLAINT: Stated by the father “M.H. keep complaining of earache and on and off fever”

Sickle cell anemia is an anemia that is inherited and mostly affects people whose heritage can be traced back to places where malaria was prevalent. There are approximately 100,000 Americans that have the disease and many more with the trait. Several of my family members are afflicted by this medical condition that causes red blood cells to take on an irregular shape.

Sickle cell disease is an inherited form of anemia. This means both parents must pass on the defective gene for a child to be affected. The gene is more common in families that come from Saudi Arabia, Africa, Mediterranean countries, India, the Caribbean islands, and North, South, and Central America of African descent.

Locate, cite (quote or paraphrase) and share a reliable information source(s) that discusses a degenerative disease experienced at a higher rate among Black/African Americans (vs. American majority statistics)

All of the cells within the tissues of the body need a regular supply of oxygen to function. The hemoglobin found in red blood cells (RBC’s) are essential for the proper transport of oxygen molecules. They bind oxygen in the lungs and carry to every tissue within the body. Due to the structure of hemoglobin, normal RBC’s are donut shaped with a concaved center. This flexible shape is what allows the BRC’s to move freely into very small spaces such as capillaries where they will deliver their oxygen. Sickle cell anemia or other diseases that fall within the broader group of disorders characterized by SCD describe conditions where the protein (hemoglobin) has misfolded and altered the shape of the cell. Sickle hemoglobin allows for the formation of stiff rods within the red blood cell giving it a sickle, or crescent shape. This new shape is not flexible and can block or slow the flow of blood. When this occurs, oxygen cannot reach its intended tissues. This results in severe pain called crises, and these attacks occur

Hemoglobin in red blood cells takes the oxygen to the lungs and transports it to all of the tissues in the body. Normal red blood cells have hemoglobin that is disc-shaped, allowing for very important flexibility through small and large blood vessels to deliver the oxygen needed. Red blood cells in SCD are not disc shaped, instead they are shaped like a sickle, or a crescent. The sickle-shaped red blood cells can become stuck to the walls of vessels and cause a blockage of blood

Sickle cell anemia is a disorder that is caused by the abnormal shape of hemoglobin cells in the body. In lecture we learned that hemoglobin is the molecule that is present in red blood cells. Hemoglobin is responsible for supplying oxygen to other cells throughout the body. Red blood cells are normally rounded in shape, defected cells are in a long shafted shape, which gives the disease its name. When red blood cells sickle, they break down which causes anemia of the cells. Sickle cells can result in an individual having a low red blood cell count, having repeated infections, and suffering from long episodes of pain in different parts of the body. The disease can also cause delayed growth in children, shortness in breathe, fatigue, swollen feet and hands, and also vision problems.

Sickle cell disease is a hereditary blood disorder caused by an abnormal hemoglobin in the red blood cell. Hemoglobin is a type of protein that carries oxygen in the body. In order for someone to have sickle cell disease they would need to have been passed down from at each one of their parents, by inheriting a total of two hemoglobin genes. The fact that this is a hereditary disease means that it is not considered to be contagious. This disease comes in about six different forms, but the most severe of them all is sickle cell anemia. Sickle cell is an inherited disease that affects the red blood cells causing debilitating symptoms, however, with treatment people with this disease can quite possibly live an otherwise

Sickle Cell Disease is an autosomal recessive genetic disease that occurs due to a mutation in the β-globin gene of hemoglobin. Autosomal meaning that it is not linked to a sex chromosome, so either parent can pass on the gene to their child. This mutation is a result of a single substitution of amino acids, Glutamic for Valine at position 6 of a β globin chain. The presence of this mutation causes

Even the slightest changes within a single protein may greatly affect the health of a human being and their descendants. Sickle cell blood anemia is a type of blood disorder in which the proteins within the affected person have slightly mutated in order to form a sickle shaped cell. This can cause chronic health problems to a patient that has sickle cell anemia since their sickle shaped blood cells may obstruct their circulatory system. Despite this disease being chronic, a patient can only get sickle cell anemia if they have inherited it. Sickle cell anemia is most commonly inherited by African Americans and Hispanics. In other words, sickle cell anemia is a chronic disease in which a person is inheritably born with some sickle shaped blood

Sickle Cell Disease can be inherited from your parents. If both of the parents are carriers for Sickle Cell, there is a 25% chance of having a child with SCD, a 50% chance of having a child with SCT, and a 25% chance of having a normal child. If both parents are normal, and are not carriers of SCD, than

In high-income countries like the United States, the life expectancy of a person with SCD is now about 40–60 years. In 1973, the average lifespan of a person with SCD in the United States was only 14 years. Advances in the diagnosis and care of SCD have made this improvement possible. Sickle Cell disease affects mostly African, Mediterranean and related ancestries it is passed on through generational traits and common related blood type. Sickle Cell disease is a disease that causes painful attacks called crises; which causes throbbing in their bones and backs. Sickle cell is caused by a protein that is abnormal called hemoglobin S which causes the shape of red blood cells to change into a sickle or crescent type shape. (George Buchanan, 2010) Cells in tissues need a steady supply of oxygen to work well. Normally, hemoglobin in red blood cells takes up oxygen in the lungs and carries it to all the tissues of the body. Red blood cells that contain normal hemoglobin are disc shaped (like a doughnut without a hole). This shape allows the cells to be flexible so that they can move through large and small blood vessels to deliver oxygen. Sickle hemoglobin is not like normal hemoglobin. Sickle-shaped cells are not flexible and can stick to vessel walls, causing a blockage that slows or stops the flow of blood. When this happens, oxygen can’t reach nearby

Sickle cell disease is categorized as an autosomal recessive disease. That means in order for one to inherit the disease, they must inherit two recessive alleles for sickle cell disease, or hemoglobin S gene. Having only one recessive allele makes you a carrier. The disorder causes the affected person’s red blood cells to disfigure into a crescent or sickle, which differs from the normal red blood cells that shaped into a doughnut. Sometimes, cells in a sickle shape cannot get through the narrow passageways of the blood vessels as easily as normal red blood cells. This blocks blood from entering and oxygen can’t reach the affected person’s organs. It can also crystallize and block arteries and