Research Paper On Sepsis

Sepsis and Septic Shock have been my personal topic after the life of young Kamil Williams and a 31-year-old Texas man who both contacted a bacterial infection later turn into sepsis. Although I have not formally studied it during my school or university years, I still find the human body, how it can break down and react to certain ailments interesting. The next question would be why does this happen? Well when there is infection or insult upon the body’s immune system normal reacts and causing an inflammatory response. This normally a good thing and it promotes healing and the resolution of the insult, however in Septic Shock the inflammatory response comes explosive and uncontrollable. According to Allison Hotujec, the author of “Severe Sepsis and Septic Shock Protocols,” Sepsis has been called a “malignant intravascular inflammation.” The term malignant is because it is uncontrolled unregulated and self-perpetuating, in the usual immune response here is release of both pro-inflammatory and anti-inflammatory mediators, these balance to promote tissue

Sepsis is a life-threatening and potentially fatal condition caused by the body’s reaction to an infection. Sepsis occurs when chemicals normally released in the bloodstream to fight infection trigger inflammation throughout the body. This can result in damage to multiple organs, which can cause organ damage and, in some cases, death.

The systemic inflammatory response is the next step in the continuum and is a nonspecific inflammatory state that may be seen with an infection. Sepsis is the presence of the systemic inflammatory response syndrome (SIRS) with evidence of infection. As the bacteria invade the bloodstream, they release endotoxins that damage the endothelial cell lining and impair the vascular system, coagulation mechanism, and immune system. These endotoxins also trigger the immune and inflammatory responses, which results in the activation of macrophages and CD4 cells that release proinflammatory cytokines to create a systemic inflammatory response to the pathogen. Hospitalized patients may quickly progress from bacteremia to sepsis and finally to septic shock, even with treatment.

This is the case study of Mr. Jones, a 65 year old male, who was admitted to the emergency department with persistent cough and episodes of chest pain over the last five days. He appeared to be experiencing worsening dyspnoea, fever and feeling unwell. It was also noted that he had a poor urine output over the last 24 hours. An indwelling catheter was inserted which only obtained 20 mLs of amber urine.

Not all bacteremias lead to sepsis. People have everyday bacteremia, particularly, from oral cavity, but sepsis develops rarely [27-31]. It occurs when the infection is resistant to host antibacterial defense. The latter is different in the bloodstream and tissues. If the infection develops locally (tissue, cavity, etc.) and then enters the bloodstream, there are two stages of sepsis: pre-septic (local) and septic (generalized). If infection enters the bloodstream directly from an external source (contaminated intravenous injection, bite, etc.), the pre-septic stage is absent. Local antibacterial defense is provided by phagocytosis (leukocytes and their local versions: resident macrophages), complement, NETs, etc., whereas in the bloodstream

Sepsis is the number one cause of death in intensive care units in the U.S. More than 750,000 cases of sepsis occur each year and about one third of those patients die from it (McKinney, 2014; Ulloa, 2011). Sepsis is a serious condition that is a result of an inflammatory response to infection that can damage organs if left untreated. Severe sepsis occurs when the infection leads to organ dysfunction. Septic shock is when multiple organ failure occurs due to infection and is worse than sepsis and severe sepsis.

Sepsis is a potentially fatal medical condition where the blood is overwhelmed by the presence of bacteria; activating the immune response and potentially causing organ dysfunction due to the disruption of homeostasis, tissue perfusion and limited oxygen supply. Systemic inflammatory response syndrome can be a key to the recognition of the illness. This condition can be treated with antibiotics intravenously or by draining the infected fluid. However, treating the infection with appropriate anti-microbial medication does not always cure the illness. Understanding the activation of inflammation, coagulation and fibrinolysis in the pathophysiology of sepsis, has allowed further research and development of therapeutic agents in its clinical

Sepsis is a rapidly progressive illness that must be treated early with antibiotics and supportive care.

Septicemia is an infection from a life threatening complication, such as pneumonia, kidney infections, a gunshot wound or have been severely burned. Septicemia is also known as bacteremia or blood poisoning, if it is left untreated it might progress into sepsis. Some symptoms pertaining to Septicemia are reduced urine volume, rapid respiration, fever and confusion to think clearly.

et al., 2008). Sepsis is a frequent cause of admission to intensive care units (ICUs) and it

Outpatient services are medical procedures that do not requires an overnight stay. Outpatient usually cost less because many procedures and tests are done in few hours. The following are the outpatient facilities that I would considered for employment; urgent care clinic, rehabilitation center, and doctor’s office.

Is sepsis complicated by organ dysfunction, is diagnosed in more than 750,000 patients per year and has mortality rates as high as 28%-50%.

According to numeral cases related to the following topic, blood poisoning can be a life threatening situation, varying on how extensive someone has had it for. The genuine name of blood poisoning is called Sepsis, documented from healthline.com. If Sepsis is not treated when noticed, the person who has it will likely undergo aches and distress from the symptoms, possibly resulting that it may end in tears. If one believes that he or she may have Sepsis, then it is recommended that the person seeks medical attention immediately. If it occurs and the person can not drive there, call an operator to send an ambulance. After doing so, talk with the person who has it to calm them down, to ensure that he or she  go into shock. Blood poisoning

Sepsis is a debilitating, potentially life threatening condition that has become a big burden on the health system worldwide. Early recognition and aggressive timely treatment have proven to be life saving interventions. South Miami Hospital (SMH) aims to provide safe care to our community by implementing and utilizing evidence –based guidelines and protocols. According to research, early identification of patients presenting with signs and symptoms of sepsis is crucial to patients’ survival. In order to achieve this goal SMH Emergency Department (ED) implemented a triage sepsis-screening tool, an intervention that as evidenced by research helps to recognize patients at risk for developing sepsis or presenting with this devastating disease.

Septic shock results from bacteria that multiply in the blood and then releases toxins that decrease blood pressure, thus, impairing blood flow to cells, tissues and organs. It is an acute infection, usually systemic, that overwhelms the body (toxic shock syndrome) (Huether & Mccance, 2012). This