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Renal Blood Flow Changes

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As aging progresses, the kidneys begin to lose anatomical structures and physiological functions. Only 3% of the elderly have normal kidney structure and function (Mareib and Hoehn, 2012). This is most commonly observed by the loss of renal mass; this can start in early adulthood and 50-90g can be lost. At 90 years old the kidneys weigh 20-40% less than that at 30 years (Saladin, 2010). This loss starts from ages 30-59, and is most considerable from ages 60-70 (Čukuranović and Vlajković, 2005). The loss in renal mass can be primarily attributed to the cortex area and the decline in renal blood flow (Čukuranović and Vlajković, 2005). The changes in renal blood flow will be discussed later. The cortex mass loss is due to the loss of 30-40% the amount of functional nephrons. After the kidney length peak at ages 20-30, there is a subtle shrinking until age 60 and then the decrease accelerates (Čukuranović and Vlajković, 2005). Renal Blood Flow Changes …show more content…

This change in RBF is most apparent in age 50 and will steadily decline by 10% per decade (Digiovanna, 2000). This decline is due to a multitude of dilation and constriction changes. Firstly, the renal arteries (e.g. accurate and interlobular) lose their shape and curve. Secondly, calcium builds up on the renal artery walls. Finally, the increased production of endothelin-1 and nitric oxide is responsible for the decline in renal blood flow (Čukuranović and Vlajković, 2005). The decline in RBF is the main cause for most the of the declines in renal physiological function: filtration, reabsorption, and hormone secretion (Digiovanna, 2000). The use of nonsteroidal anti-inflammatory drugs (NSAIDS) can also lead to arterial constriction and can further the aging affects on RBF (Digiovana,

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