Glomerular Filtration
Activity 1: Effect of Arteriole Diameter on Glomerular Filtration
1. Compare this data with your baseline data. How did increasing the afferent arteriole radius affect glomerular filtration rate?
>>Increasing the afferent arteriole radius pushed the glomerular pressure, the glomerular filtration rate, and the volume of urine to be higher than the baseline data. Increasing the afferent arteriole radius increased the glomerular filtration rate. 2. Under these conditions, does the fluid flow through the nephron?
>>No! No urine was collected which indicates no fluid flows through the nephron.
3. What is the glomerular filtration rate?
>>The glomerular filtration rate is 0 which
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>>Both decreased.
2. How could you adjust the afferent or efferent radius to compensate for the effect of the reduced pressure on glomerular filtration rate and urine volume? Use the simulation to determine your answer.
>>Increase the afferent radius or decrease the efferent radius.
3. What changes are seen in nephron function when the valve is closed?
>> There was no glomerular filtration rate and no urine production.
4. Why were these changes seen?>> When the valves are closed simulating blocked collecting ducts, the built up pressure caused by the increased solute volume opposes the forces driving up the filtration tasks of the kidney. The nephrons could burst if the filtering task is continued so the kidney is just trying to save ‘itself.
5. Is the kidney functional when the glomerular filtration rate is zero? Explain your answer.
>>No. When glomerular filtration rate is zero, it means nothing is filtered. The kidney is dormant and not carrying out any upfront task to stay functional.
6. What is the major “ingredient” that needs to be removed from the blood?
>>Urea along with different metabolic salts.
7. Studies on aging have demonstrated that some nephrons may fail as we get older. Will this be a problem regarding urine formation?
>>Aging causes inevitable physical and physiological degenerations and the
For P4, I’m going to outline the physiological overview of the kidneys and then I am going to explain the renal system. Also I am going to explain the kidneys in more detail.
Deacreased vascular resistance and increased arterial pressure causes an increase in blood flow. This is important to supply organs with oxygen. 4. Restate your predictions that were correct and give data from your experiment that support them. Restate your predictions that were not correct and correct them with supporting data from your experiment. MAP would increase due to increase in activity, SVR would decrease due to decrease in resistance, CO would increase due to more force of blood being expelled.
2. State the null hypothesis for the Baird and Sands (2004) study that focuses on the effect of the GI with PMR treatment on patients’ mobility level. Should the null
The C02 is low because of the low kidney function. This can also be caused by lung function as well.
1. Explain the effect that increasing the Na+ Cl- concentration had on osmotic pressure and why it has this effect. How well did the results compare with your prediction?
Secondly, osmosis was to be observed to gain a proper understanding of how the principal of dialysis functions.
* C) If you develop emphysema the kidneys will remove fewer bicarbonate ions from circulation
i. why there is a delay in the onset of the diuresis after water loading in the control subject (A);
of the water. The osmolality of the water leaving the tube of Henle is lower than the
In Kidney failure cases urea, creatine, uric acids and electrolytes move from the blood to the dialysate with the net effect of lowering their concentration in the blood. RBC s WBC s and plasma proteins are too large to diffuse through the pores of the membrane. Hemodialysis patient are exposed to 120 to 130 L of water during each dialysis treatment. Small molecular weight substances can pass from the dialysate in to patient’s blood. So the purity of water used for dialysis is monitored and controlled.
CKD will cause the body to retain many excess fluids and waste that are normally filtered out to prevent internal harm throughout the body. With kidney disease there will be a rise in blood pressure due to the amount of extra fluid that is retained in the blood vessels. This fluid retention will cause the passageways to become narrow and make blood passage through the vessels increasingly difficult, in turn causing an increase in blood pressure. There will also be an increase in protein and blood found in the urine because it is not filtered out properly by the kidneys. Swelling will occur in the extremities and around the eyes because of the fluid retention as well. The longer the urine goes unfiltered the harder it may become to urinate due to pain or blockage or there may be more frequent night time urination (The National Kidney Foundation, 12).
Consider a fluid restriction to prevent possible fluid overloading due to his decreased renal function (Vera, 2011).
The major objective of the experiment was to test the effect of the concentration gradient on the diffusion rate. It was hypothesized that the greater the stronger the concentration gradient, the faster the rate of diffusion would be. To test this, dialysis tubes were submerged in different concentration fructose solutions. We weighed the tubes at specific time intervals to measure the rate of diffusion of water in each different solution. The results illustrated that increased concentration gradient increases the rate of diffusion of water in the tubes. We concluded that as concentration of the
mediators, causing increasing capillary permeability and widespread fluid shift into the interstitial space, which was no longer functioning to maintain vascular volume (known as third spacing) in addition, causing further vasodilation to occur.