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Pruriceptive Itch

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For the most part we all itch subconsciously to gain relief from minor disturbances on our skin. But most of us have probably experienced itches that go far beyond this level to the point where an itch can take over you entire mind for several minutes. As an example of a more extreme case a patient with HIV from Massachusetts developed a severe deep crawling itch on the right side of her scalp in response to shingles medication. Her scratching intensified at night time and one unfortunate morning she woke up to find green liquid on her hands. When she got to the hospital she was immediately admitted into an Emergency department. She had scratched through her skull and into her brain (Gawande).
Scientists classify itches in four categories pruriceptive (skin irritation and inflammation), neuropathic (chronic itching due to nerve damage), neurogenic (activation of the CNS without stimulus), and psychogenic (mental illness). Pruriceptive itch, the most common type, can be triggered by stimulation of pruriceptors by mechanical, thermal and even chemical mediators such as histamines which are part of our body’s immune response (HowStuffWorks).
It is easy to think that the need to itch is …show more content…

The authors also make the important observation that pain has the ability to suppress itch which is shown when the mechanical pain of a scratch masks an itch, but never see an itchy sensation relive pain (Sun). This led the authors to believe that pain and itch have common neuronal paths but somehow our CNS is able to distinguish these sensations. Their new selectivity theory claims that itch stimuli are itch neuron specific while painful stimuli activates a wide range of neurons that ultimately inhibits the itch sensation while producing the pain

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