Parkinson 's Disease ( Cns ) And The Peripheral Nervous System

Parkinson’s disease is a progressive neurological condition which occurs when the brains nerve cells that contain/produce dopamine die, without the chemical

Our nervous system is there to help to transfer the things our body feels and what we need. The nervous is broken up into two parts, the central nervous system (CNS), and the peripheral nervous system (PNS). The CNS controls the brain and the spinal cord, the PNS controls the nerves and the ganglia (a small mass of gray matter). Our body uses the spinal cord to send messages to the nerves so that it can control our organs and muscles.

Parkinson's Disease is a literally crippling neurodegenerative disorder, manifested in about 1% of the aged population. People who have Parkinson's Disease gradually lose control of their movements; specific symptoms include, "tremor, slowness of movement, stiffness, difficulty in walking, and loss of balance." (1) Evidence strongly suggests that Parkinson's Disease is the result of severe cell loss in the substantia nigra. This brain structure is principally involved in the production of dopamine. (2) Dopamine, among other functions, is the neurotransmitter involved in initiation of movement. Hence, the link between dopaminergic cell loss and cessation of voluntary movement, as manifested

Parkinson disease (PD) is one of the most common neurologic disorders. and it affects approximately 1% of individuals older than 60 years old. Parkinson’s disease is a condition that progresses slowly by treatment. In addition, loss of pigmented dopaminergic neurons of the substantianigra pars compacta and the presence of Lewy bodies and Lewyneurites are the two major neuropathologic findings in Parkinson disease (Hauser, 2016).

The peripheral nervous system (PNS) is connected directly to the central nervous system, and consists of neurons and nerves that send information back and forth the CNS. Furthermore, the peripheral nervous system can be divided into two sections, the sensory nervous system and the motor nervous system. The Sensory The sensory nervous system is in charge of transmitting data from a variety of internal organs or from external stimuli to the central nervous system using sensory nervous cells. On the other hand, the cells of the motor nervous system (motor neurons), take the impulse from the CNS to effectors, which include glands and muscles. In addition, the motor nervous system can be further divided into the somatic nervous system, controls voluntary actions of the skeletal muscle and external sensory organs, whilst the autonomic nervous system operates

Parkinson’s disease is caused by the destruction of dopamine-producing nerve cells in the midbrain (Substantia nigra). These nerve cells are used to coordinate smooth and regular body movement. In the absence of these cells, people often experience tremors (involuntary shaking or

Parkinson’s is a progressive neurodegenerative disease, primarily affecting voluntary, precise, and controlled movement. Parkinson’s occurs when cells in a part of the brain called the substantia nigra die off. These cells are responsible for producing dopamine. With less and less dopamine, a person has less and less ability to regulate their movements, body and emotions. The terms "familial Parkinson's disease" and "sporadic Parkinson's disease" are used to differentiate genetic from truly idiopathic forms of the disease.

Parkinson disease (PD) is a progressive neurodegenerative disorder characterized mainly by physical and psychological disabilities. This disorder was named after James Parkinson, an English physician who first described it as shaking palsy in 1817 (Goetz, Factr, and Weiner, 2002). Jean- Martin Charcot, who was a French neurologist, then progressed and further refined the description of the disease and identified other clinical features of PD (Goetz, Factr, and Weiner, 2002). PD involves the loss of cells that produce the neurotransmitter dopamine in a part of the brain stem called the substansia nigra, which results in several signs and symptoms (Byrd, Marks, and Starr, 2000). It is manifested clinically by tremor,

Dopamine is a brain chemical/Neurotransmitter that work as messenger signal between the Substantia Nigra to the next relay station of the brain, the corpus striatum which helps to produce smooth coordinate movement and also plays a major role to help control muscle’s movement. With Parkinson’s disease, the brain cells that produce dopamine slowly die, which lead to decrease production of Dopamine. The loss of dopamine causes abnormal nerve firing with brain and the cells that control muscle’s movement by sending the messages to the muscles; due to this it becomes really hard to control muscles movement and cause tremors and various other symptoms such as rigidity and difficulty walking and performing daily tasks. Dopamine is not the only neurotransmitter involved in Parkinson’s Disease. Norepinephrine is very relatively close to dopamine and is also involved in Parkinson’s Disease. Individuals with Parkinson’s Disease have loss of nerve ending that produce norepinephrine. Norepinephrine is a major neurotransmitter for sympathetic nervous system, which control many autonomic functions of our body; it causes increase in blood pressure and heart rate. Loss of norepinephrine can help us explain the non-motor symptoms associated with Parkinson’s Disease such as fatigue, decrease in gastric stability and disruption in cognition. Parkinson’s Disease can be hereditary

The human nervous system is divided into two parts, the central nervous system and the peripheral nervous system. The central nervous system, CNS, is just the brain and spinal cord. The peripheral nervous system, PNS, includes the nerves and neurons that extend outwards from CNS, to transmit information to your limbs and organs for example. Communication between your cells is extremely important, neurons are the messengers that relay information to and from your brain.

Parkinson Disease (PD) is a neurodegenerative disease symptomized by tremor, muscular rigidity, and slow imprecise movements. Typically, the disease affects middle-aged and elderly individuals. PD is associated with degeneration of the basal ganglia of the brain causing a deficiency of the neurotransmission of dopamine.

Parkinson’s Disease is a multifactorial disease which means it does not have one specific disease. Multifactorial diseases, such as Parkinson’s Disease, are caused by both genetic and environmental causes. PD is known to be linked to “a deficiency of dopamine neurons.” Scientists know that the cause of Parkinson's Disease is due to the death of dopamine cells in the substantia nigra and basal ganglia;(Abromovitz 28-30) however, no one is sure what causes these neurons to die.

Parkinson’s disease is one of the most common forms of Parkinsonism, which are a group of motor system disorders. Parkinson’s is a genetic disorder that occurs primarily when a person has low and/or deteriorating dopamine levels. Dopamine neurons are important in the role of voluntary movement and mood. Dopaminergic neurons are made in the substantia nigra, in the brain and as the number of neurons drop the severity of the symptoms become more severe. No one knows what triggers the death of these cells. The remaining surviving cells that are affected usually present with Lewy bodies and Lewy neurites (Wakabayashi et al. 2012). Typically, Parkinson’s disease affects people past the age of 65, but like many diseases,

Parkinson's disease is a neurodegenerative disorder, which leads to progressive deterioration of motor function due to loss of dopamine-producing brain cells.

Parkinson’s disease is affected by the degeneration of dopaminergic neurons which is responsible to produce dopamine. Dopaminergic neurons have their cell bodies in substantia nigra pars compacta (SNpc) in basal ganglia (O’Sullivan and Schmitz, 2007). Basal ganglia are a collection of interconnected gray matter nuclear masses deep within the brain”. These gray matter masses are caudate, putamen, globus pallidus, subthalamic nucleus and the substantia nigra. Basal ganglia receive its input through striatum (O’Sullivan and Schmitz, 2007).