Natural Killer Research Paper

The green river killer is a man known by the name of Gary Ridgeway on the surface he lead a seemingly normal life, head down a regular job and was married. Ridgeway began his murders in 1982 by murdering young prostitute who were runaways.Many of these girls were minorities. He dumped the bodies of his victims  in the Green River which ultimately gave him the name the Green River killer because he dumped all of his bodies in the same river. From the beginning of his crime spree there were many dead bodies but no good leads on who the murderer was. It wasn't until 2001 when more technology became available that the case was reopened.  The specific technology that they used to solve this cold case  was DNA. In 2003 he pleaded guilty to 48 counts

Lymphocytes are vital to the human body to protect us against disease and initiate an immune response. Each person possesses billions of lymphocytes which collectively provide an individual with the ability to respond to a huge variety of antigens. The wide

I am playing the Anti Hunter Activist role in animal rights. I am going to be fighting against people who do hunting, fur trapping, pigeon shooting and Alaskan Wolf hunts. I will be dressing up in camo and have a big red line through it to show that I am against Anti- hunting activist. The props I will use to show how hunters use animal props. I will use an intimal letter made out animal antlers, Uggs that are made out of sheep skin. I will also use a handout out that better explains fur trapping and pigeon shooting.

Serial crimes have been on the rise in the last couple of years. The number of reported cases of people found to have been murdered in mysterious ways has dominated news headlines across the world. Serial offenders have a tendency of repetition of same crimes. There are certain factors which are believed to be the motivating factor of serial offenses. In this discussion, some of the factors that are seen to significantly contribute to serial offenses have been discussed.

The mind of a serial killer is obviously different than the mind of a typical person, whether it’s from an experience they had or they were just born with a problem in their brain. The reason they are different that the typical human is because they may not feel any remorse when taking another one’s life. A chemical imbalance in the brain could be the explanation why they are like this or they may have a mental disorder or there could be more to it. Could there be another reason why they kill others? Do they see pleasure out of the deal?

Immunology basically involves understanding the immune system and how it responds to various disease conditions. the immune system consists of a number of components. Traditionally, it is divided into humoral and cellular immune responses. It can also be distinguished into innate and adaptive immunity. The innate immunity can discriminate between normal tissues , self and newly encountered non-self-proteins while the adaptive immunity is the more complex system aimed at the eradication of intracellular pathogens. To do this, antigen derived from such pathogens that are often new to the host organism, need to be recognised by receptor-bearing specialised immune cells which respond to a complex system of stimulatory and costimulatory signals. Better understanding of the human immune system has led to the identification of a number of tumor-associated antigens in the 1980s and the development of various immunotherapeutic approaches. In recent years, identification of the specific antigenic MHC class I epitopes, advancements in genetic engineering, gene delivery, and cell-based therapeutic approaches allowed development of the novel immunotherapeutics.

The immune system is made up of trillions of specialised cells (white blood cells) that detect and destroy pathogens or their toxins. Some white blood cells, which are

Natural Killer (NK) cells are immune cells which are kenned to exhibit cytotoxicity towards various types of cancer cells during metastasis (spread to other organs) [53, 54]. Natural Killer (NK) cells cytotoxicity has been found to be enhanced by G. lucidum towards a variety of tumors [55].

Background: Innate immunity is the first line defense against invading microbes pathogens. Human blood is full of cells that express immune system such as Neutrophils. The most important operation that Neutrophils do in this lab is phagocytosis. Phagocytosis is normal reaction white blood cells doing when human body is under attack from bacterial pathogens.

In immunocompetent hosts, viral titers in the lung increase 1-2 days post-infection, reach a maximum at 3-5 days, start to decline at day 7, and are cleared between day 9 and day 14 (19). Early (day 2) p.i., the viral titers in the lungs of WT and NK-depleted mice were identical (not shown). As viral replication reached more significant levels at day 4 p.i., there was a trend toward increased viral load in NK-depleted animals, but these did not reach statistical significance (Fig. 5D). At day 6 p.i., a time point at which peak numbers of IFN-γ+ NK cells occur in the lung, a significant increase in VACV titer was observed in anti-NK1.1-treated mice, and this high titer continued in some animals through to day 9. Despite this, both NK-depleted and untreated NK-sufficient WT controls cleared VACV between day 9 and day 14, directly correlating with the kinetics of weight loss recovery. To further assess the anti-viral activities of NK cells, we investigated the dissemination of VACV from the lung to peripheral tissues. At day 4 p.i., there was a 10-fold increase in VACV titers in ovaries from NK-depleted mice (not shown). Again, VACV titers continued to increase over the next two to five days but were minimally detectable by day 14 (not shown). Notably, NK-depletion did not affect all organs, because an increase in infectious virus was not found in the liver, spleen, heart, and kidneys (not shown). These data suggest that NK cells provide a temporary barrier limiting VACV replication and dissemination during the acute phase of

Immunoglobulins that are vital to the host immunity are absorbed through specific receptors (called as Fc receptors)

The adaptive immune response is antigen-specific and requires the recognition of specific “non-self” antigens during a process called antigen presentation. Antigen specificity allows for the generation of responses that are tailored to specific pathogens or pathogen-infected cells. The ability to mount these tailored responses is maintained in the body by "memory cells". Should a pathogen infect the body more than once, these specific memory cells are used to quickly eliminate it. so basically killer T cells will identify antigens present on foreign cells. These antigens are not found in any of the cells inside our body. So T cells will identify them and kill them.

The key role of NK cells in various aspects of immune response are now being recognized and have been attracting increased attention for their potential clinical efficacy via immune-based therapies. As their name implies, this unique member of the innate immune system can recognize targets without being previously sensitized and thus kill cells that are deemed dangerous to the host. This is particularly important when evaluating biologic studies of NK cells and factors that influence NK-cell effect in cancer immune-surveillance, viral immunity, and transplantation alloreactivity. In this chapter, we will review NK cell biology, discuss their role in the alloHSCT setting, and review new advances in incorporating NK cells as therapeutic options for malignancies. Large granular lymphocytes (LGL) can be divided broadly into two major lineages mainly T cells and natural killer (NK) cells. While mature cells NK cells are morphologically identified as LGL, nearly a decade after their initial discovery, NK cells were characterized as lymphocytes having an immuno-phenotype that lacked expression of CD3- but expressed CD56+. This characterization thereby differentiated them from T-cells having CD3+ expression and thus NK cells do not express the CD3/T-cell receptor (TCR) complex or experience TCR gene rearrangement. NK cells can be further divided into two distinct

Now I wish to share with you three of the ways I evade the immune system efficiently. I have learned to be really sneaky and evasive over the years of fighting with the pesky immune system. One of my favorite ways I evade the immune system is by tricking your Natural Killer (NK) cells into thinking the cells around them are healthy, even when I have actually already infected them. NK cells typically induce apoptosis in cells that are stressed. Cells indicate that they are stressed by displaying a decreased amount of Major Histocompatibility Complex I (MHCI) on their surface. So I had to think of a way to prevent NK cells from binding to the cells that I infected and keep a normal level of MHCI displayed on the infected cell surface. I did this simply by producing fake MHCI that will be displayed on the infected cell surface. My fake MHCI resembles the real MHCI so closely that the NK cells are tricked into not inducing apoptosis in the infected cell. If that does not convince you of how much smarter I am than your immune system, just wait. I will share with you two more ways in which I evade my

B cells are a third class of important immune system cells. They do not kill the invaders, but they do tell the killers who to kill. B cells produce specific protein called Antibodies. Each B cell watches out for a particular pathogen and when that pathogen arrives, e B cell begins to produce specific antibodies. Antibodies attach themselves to the specific pathogen so that the killers can recognise that these pathogens need to be destroyed.