Perioperative Diagnosis and Treatment of Serotonin Syndrome Following Administration of Methylene Blue 1. James Francescangeli, MD Title: Dr. Affiliation: Penn State Milton S. Hershey Medical Center Email: jfrancescangeli@hmc.psu.edu Conflicts: James Francescangeli reported no conflicts of interest Attestation: James Francescangeli approved the final manuscript 2. Sonia Vaida, MD Title: Dr. Affiliation: Penn State Milton S. Hershey Medical Center Email: svaida@hmc.psu.edu Conflicts: Sonia Vaida reported no conflicts of interest Attestation: Sonia Vaida approved the final manuscript 3. Anthony Bonavia, MD Title: Dr. Affiliation: Penn State Milton S. Hershey Medical Center Email: abonavia@hmc.psu.edu Conflicts: Anthony Bonavia reported no …show more content…
Hershey Medical Center 500 University Drive, H187, Room C2833 Hershey, PA 17033 Phone: 717-531-6140 FAX: 717-531-5449 Email: abonavia@hmc.psu.edu Information for LWW regarding depositing manuscript into PubMed Central: This paper does not need to be deposited in PubMed Central. Submitted as a Case Report The author states that the report describes the care of one or more patients. The patient consented to publication of the report. This is described in the report. This manuscript was not screened for plagiarism. Link to Title Page: http://www.aaauthor.org/pages/11148-2015-Aug-06 Abstract With the increased clinical use of serotonergic medications and methylene blue, the incidence of serotonin syndrome can be expected to increase. We describe the perioperative management of a patient taking trazodone and duloxetine who experienced serotonin toxicity intraoperatively following the administration of methylene blue. We thus illustrate the challenges in making this diagnosis in a patient under general anesthesia, and the vigilance anesthesiologists should demonstrate when managing patients at risk. …show more content…
He was also agitated and diaphoretic with flushed skin. On examination, he was noted to have rhythmic myoclonic activity notable on attempt to grasp objects. He also demonstrated spontaneous clonus of his lower extremities, lip-smacking and uncontrolled tongue movements. Based on these criteria, a diagnosis of serotonin toxicity was made, utilizing the Hunter Serotonin Toxicity Criteria.4 Opioids and serotonergic agents were withheld, as well as his home medications of trazodone, tramadol, and duloxetine. Intravenous fluids were administered in the PACU together with 1mg of midazolam, and this resulted in a reduced heart rate and reduced agitation. The patient was subsequently admitted to the surgical intensive care unit for overnight observation. While agitated, he remained aphasic with flat affect and mask-like facial expression. A noncontrast CT scan of the head was performed to rule out any acute intracranial process, but the results were grossly unremarkable. Within 24 hours, the patient’s mental status improved and he was able to communicate, although he remained lethargic with slow and purposeful mentation. He was transferred to a regular nursing floor after 24 hours in the intensive care unit. He recovered appropriately from a surgical standpoint was discharged home four days following
Therefore it is vital to ask the patient how they would like to disclose the information and can prompt the physician to the most ideal approach to arrange the dialog from there on out. He inquired as to whether she would like him to give her all the information on the results or gave her the choice of outlining the outcomes and investing more energy in the talking about and treatment arrangement. She requested that he told her like it is and she did not want to wait any longer. This represents instrumental support and she felt as if she was an active participant and involved in decision making.
After surgery, she was transferred to the PICU. Today, she was just transferred from the PICU to Explorer-West. She is continuing to show improvement; however, she is being administered Keppra for prophylaxis of seizures. She has a dressing over her surgical wound that is currently dry and intact. The wound closure itself is closed with steri-strips. She’s currently at a GCS of 14. She is able to answer questions with soft words, nods, and shakes her head. However, she can become disorganized and agitated at times, which results in her pulling on her lines and tubes; therefore, a restraint was ordered. In addition, she has a decrease in motor ability. Her ROM, strength, and tone are all weak bilaterally in her lower extremities. She is able to ambulate with assistance only along with the use of the cervical orthosis prescribed by the physical therapist. She is currently on room air with an oxygen saturation of 100%. Her current vitals are as follows: temperature 36.9 ̊C; pulse 97; RR 23; and BP
I was so interested in reading your post because I wanted to know the other ways to manage Amitriptyline overdose since you've mentioned that there is no antidote for it. You were right when you said that cardiac condition and airway clearance must be carefully monitored to avoid complications or worst, death. It is important also for the nurse and/or the patient who is taking this drug to know the anticholinergic effects, such as dry mouth, photophobia, hallucinations, blurred vision, and tachycardia, so that proper interventions and management can be done. Because there is a high risk for suicide when this drug is taken, psychotherapy can be provided to the patients so that they can express their feelings and thoughts, hence, help decreases
During the time of the assessment the patient was alert and calm. The patient reports that for six months he has been taking Suboxone to stay off of pain pills. The patient reports that he has been getting Suboxone from friends who told him that it would get him off pain pills. The patient reports that he conflict in his marriage and with his place of employment. The patient reports that a week before Christmas his wife left him and that cause stress in his life. In addition, the
The multidisciplinary team meeting is an example of the process in action. Many clinicians are present. Most will be in a position to help formulate the most appropriate management for the patient. The doctor directly responsible presents the present situation and the relevant background. The assessment will include a discussion with the clinician to clarify the clinical findings and a joint review of the results of all relevant investigations. Recommendations will be agreed by all present. These will be documented in the patient's records for implementation.
risperidone whereas in this one there was a fixed dose to limit breach in blinding and to facilitate comparison between similar groups, also having this fixed dosage helped prevent bias because when using a titrating schedule of dosing in a randomized trial, it tends to show bias toward a desired goal. Risperidone in this study was well tolerated and there weren’t significant differences in weight gain or sedation(13). One of the main things disliked about risperidone is its tendency to increase the incidence of dyskinesia and other extrapyramidal side effects. In this study only mild and transient dyskinesias were seen in only 3 children, however that could be due to the low fixed dosage(13) of the study.
This report of central nervous system depression after the administration of recommended doses of codeine in a patient with a CYP2D6 ultra-metabolizer phenotype supports genetic testing to assist in elucidating serious adverse drug reactions and in prevention of subsequent inappropriate dosing or drug selection. Genetics testing can give insight as to how our patients process the medications we prescribe them. Pharmacogenetics is a growing field with many benefits to the patient. Our duty as providers is to stay abreast of a developing technology that will provide better outcomes for our
Olanzapine is associated with adverse effects when taken above the safe therapeutic range between 20 to 40 ng/ml, symptoms of toxicity include depression, tachycardia and hyperpryexia,, the effects of these symptoms are normally more severe in children.. Olanzapine is considered to have a low mortality rate although serious cases of olanzapine toxicity can lead to possible death. In postmortem examinations olanzapine is not normally the main cause of death, but is a contributing factor therefore the involvement of other drugs need to be considered. Early detection of toxicity is vital although activated charcoal has previously been beneficial in the treatment for an overdose of olanzapine (Chue, P., Singer, P., (2003)).
In Figure 3.1 where the partial rates of diffusion of each substance was plotted at a three-minute intervaland also in Figure 3.2 where the comparisons are seen, Potassium Permanganate increased after three minutes ahead and remained its value until the sixth minute and it remained constant, Potassium Dichromate increased at the sixth minute and retained its increase until the ninth minute and then remained constant, while Methylene blue remained constant all throughout in the 30 minutes span of time. Although the average rate of diffusion calculated in Table 2 show no difference in Potassium Permanganate and Potassium Dichromate, as seen in Figure 3.1 and Figure 3.2, Potassium Permanganate diffused the faster in the first six minutes of diffusion than
During the subsequent period he was under outpatient psychiatric care delivered through approximately 4 psychiatric controls per year. Psychopharmacologic treatment included antidepressants (with conversions of several different selective serotonin reuptake-inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitor (SNRI)) prescribed regularly and anxiolytics and hypnotics prescribed as needed. In 2011 quetiapine was prescribed with intention to decrease anxiolytics utilization and expected therapeutic effect on hyperarousal symptoms. Premature ejaculation and urinary urgency persisted. Urological evaluation didn't find organic basis of the difficulties.
Internal method will be the interdisciplinary team such as hospitalist, therapists, dietician, pharmacist, case managers, discharge planners and house supervisors. These stakeholders performed a thorough discussions about patient’s admission, transfer, and discharges. Upon discussing with the patient’s overall health concerns, the evidence-based practices of bedside reporting can be part of the daily discussions because this is where the basis of patient’s health outcomes can be obtained. The goal of bedside reporting is to promote safety and highest quality of care. Therefore, the input and opinions of the whole team is very essential for the successful implementation of the bedside reporting. The bedside reporting will be more stronger tools
Both alprazolam and sertraline have possible central nervous system side effects including sedation, memory impairment, dizziness, and somnolence (Drugs.com, 2014). A medication review may be helpful in identifying problems related to this clients medication use, thereby reducing her fall risk. Evaluation of this intervention would be done by monitoring the client’s mental status following any medication
Unusual uncontrolled movements (especially in the face, legs, arms, mouth and tongue) as this medication may rarely cause Neuroleptic Malignant Syndrome
The efficacy and safety of the drug in patients under the age of 18 years is not established. With renal / hepatic insufficiency and long-term treatment, control over the picture of peripheral blood and liver enzymes is necessary. Patients who did not take previously psychoactive drugs respond to the drug at lower doses compared to patients taking antidepressants, anxiolytics or alcohol. With endogenous depression, alprazolam can be used in combination with antidepressants. With the use of alprazolam, patients with depression have seen cases of hypomanic and manic development. Like other benzodiazepines, alprazolam has the ability to induce drug dependence in long-term admission in large doses (more than 4 mg / day). With a sudden discontinuation of alprazolam, there may be comeback syndromes, such as depression, irritability, insomnia, increased sweating, especially with prolonged admission (more than 8-12 weeks). When patients develop such unusual reactions as increased aggressiveness, acute excitations, feelings of fear, thoughts of suicide, hallucinations, increased muscle cramps, difficult sleep, superficial sleep, treatment should be discontinued. During pregnancy Xanax is very dangerous due to its toxic effect on the fetus and increases the risk of congenital malformations when applied in the first trimester of pregnancy. Admission of therapeutic doses in later periods
This condition can be caused by taking medicines or drugs that increase the level of serotonin in your body. These include: