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Methylene Blue Case Study

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Perioperative Diagnosis and Treatment of Serotonin Syndrome Following Administration of Methylene Blue 1. James Francescangeli, MD Title: Dr. Affiliation: Penn State Milton S. Hershey Medical Center Email: jfrancescangeli@hmc.psu.edu Conflicts: James Francescangeli reported no conflicts of interest Attestation: James Francescangeli approved the final manuscript 2. Sonia Vaida, MD Title: Dr. Affiliation: Penn State Milton S. Hershey Medical Center Email: svaida@hmc.psu.edu Conflicts: Sonia Vaida reported no conflicts of interest Attestation: Sonia Vaida approved the final manuscript 3. Anthony Bonavia, MD Title: Dr. Affiliation: Penn State Milton S. Hershey Medical Center Email: abonavia@hmc.psu.edu Conflicts: Anthony Bonavia reported no …show more content…

Hershey Medical Center 500 University Drive, H187, Room C2833 Hershey, PA 17033 Phone: 717-531-6140 FAX: 717-531-5449 Email: abonavia@hmc.psu.edu Information for LWW regarding depositing manuscript into PubMed Central: This paper does not need to be deposited in PubMed Central. Submitted as a Case Report The author states that the report describes the care of one or more patients. The patient consented to publication of the report. This is described in the report. This manuscript was not screened for plagiarism. Link to Title Page: http://www.aaauthor.org/pages/11148-2015-Aug-06 Abstract With the increased clinical use of serotonergic medications and methylene blue, the incidence of serotonin syndrome can be expected to increase. We describe the perioperative management of a patient taking trazodone and duloxetine who experienced serotonin toxicity intraoperatively following the administration of methylene blue. We thus illustrate the challenges in making this diagnosis in a patient under general anesthesia, and the vigilance anesthesiologists should demonstrate when managing patients at risk. …show more content…

He was also agitated and diaphoretic with flushed skin. On examination, he was noted to have rhythmic myoclonic activity notable on attempt to grasp objects. He also demonstrated spontaneous clonus of his lower extremities, lip-smacking and uncontrolled tongue movements. Based on these criteria, a diagnosis of serotonin toxicity was made, utilizing the Hunter Serotonin Toxicity Criteria.4 Opioids and serotonergic agents were withheld, as well as his home medications of trazodone, tramadol, and duloxetine. Intravenous fluids were administered in the PACU together with 1mg of midazolam, and this resulted in a reduced heart rate and reduced agitation. The patient was subsequently admitted to the surgical intensive care unit for overnight observation. While agitated, he remained aphasic with flat affect and mask-like facial expression. A noncontrast CT scan of the head was performed to rule out any acute intracranial process, but the results were grossly unremarkable. Within 24 hours, the patient’s mental status improved and he was able to communicate, although he remained lethargic with slow and purposeful mentation. He was transferred to a regular nursing floor after 24 hours in the intensive care unit. He recovered appropriately from a surgical standpoint was discharged home four days following

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