The Factor of Gene Therapy: the Ethics, Progress, and Future
Abstract
Erasing genetic diseases from the human race has been a vital role in science. However, there is a point where the moral standards have interrupted the advancement of curing genetic diseases. One of the many sciences that have the ability to completely wipe out the future of any genetic diseases, gene therapy, is being stifled due to the infliction of morals. There is a fine line in what is inhumane and moral to the standards of society; causing the advancement of gene therapy to be limited. The answer to the future of gene therapy relies on what we will accomplish for the future generations, but this is based on our past, our current morals, and our cooperation.
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This hotly debated topic of whether it is dangerous “playing God” has caused many religious, political, scientific, and public figures to express their concerns in heated debates (Hogarth para 9). Ever since the beginning of gene therapy, there has been constant dispute and friction over the direction of its future; of whether gene therapy will evolve into a therapeutic science or lead to horrible consequences as the eugenics movement did in the 20th century. The ethics of gene therapy have been based on, not only the beliefs, but also the fallbacks and advantages gained in experimental trials, which has inevitably lead to the progression of the future of gene therapy. The fallbacks and progress of gene therapy are the inherent products of research that have affected its ethical aspects. Initially, when gene therapy was a novice, it gained popularity when scientific research grew toward recognizing genes that caused certain diseases (Hunt 2006). The concept of using gene therapy to cure patients diagnosed with these types of diseases became popular in the 1980’s (Hunt 2006). Starting at this period of time, gene therapy has had its ups and downs that either led the public into outrage or hope (Hunt 2006). The growing interest of gene therapy was accompanied with the controversial success of a child’s, Ashanthi’s, health who suffered from (SCID) severe combined
Gregory Stock, in his article Choosing Our Genes, asserts that at this point not ethics are important, but rather the future of genetic technology. Stock supports his conclusion by providing powerful examples of how genetic modifications can benefit our population anywhere from correcting genes at the time of conception to extending lifespan. He wants to inform his audience about all of the benefits of genetic technology in order to prove that there are way more advantages in this technology that are highly desirable by people of different ages. He reaches his readers by writing a very detailed yet coherent article that brings awareness to various groups of people from parents to be to older populations.
The Declaration of Independence describes individual rights as “the right to life, liberty, and the pursuit of happiness” (Congress). These inalienable rights are threatened by genetic modification. Specifically, Tony Wang, in his research on the ethics of genetic
In his article Is Gene Therapy a Form of Eugenics, John Harris discusses the concept of Eugenics when it comes to using Gene Therapy. Harris defines Eugenics as adapting to the production of “fine” offspring, or artificially producing offspring to fit certain criteria. He stresses on how this concept should be achieved. His main argument is that we should be in favor of Eugenics when it comes to potentially saving a child from living a potential disabled life. Harris believes that his view is not wrong, but believes that it is a matter of indifference whether we call it Eugenics or not. Harris argues that Gene Therapy is ethically sound, and
The last 150 years have seen the origin of—and rapid expansion in—human knowledge involving the nature and mechanisms of trait and disease inheritance in human beings. Advances in genetic research hold great promise for the future development of effective prevention and treatment strategies for a great many, often devastating, heritable conditions. However, these advances also raise a series of policy, legal and fundamentally ethical questions concerning what we should and should not do with the knowledge and technology we acquire. These questions are numerous and both imminently practical and speculative, ranging from the exhausted, yet still largely unresolved, question of the moral status of the human embryo to fears about slippery slopes into a Brave New World or Gattaca-style dystopic future characterized by designer children and a genetic underclass.
There have been many advances in genetic applications over the years. These improvements have sparked a slather of controversy throughout the nation. While some are excited about the realm of possibilities genetic engineering provides, most have a hard time finding the morality of it. Genetic engineering focuses on the physical and intellectual parts of life, it does not take into account the emotional and relational aspects. We need to be aware of the unintended social, personal, and cultural consequences genetic engineering provide before we continue to make harmful advances.
Worryingly, there has been minimal public debate regarding this technology that could irreversibly alter the human race. Instead, ethical discourse has been largely contained to scientific and political circles. It is extremely problematic that a large majority of the general public is unaware of the research and debate regarding human gene modification. In addition, the current debate has stagnated, with researchers and politicians being unable to find any common ground. However, upon close examination of the three main ideological groups within this controversy, a key similarity becomes apparent: each group, regardless of whether they are proponents or opponents of human gene
Genetic engineering is the figurehead of the ethical concerns of scientists in the 21st century. Nothing is more engrossed with criticism and dislike than the idea of altering the baseline for living organisms. Many people are skeptical of genetic engineering due to the versatility it exhibits. A scientist could use a genetic editing tool, such as CRISPR, to remove the genes for a hereditary disease in an embryo, but they could also utilize it to alter the physical characteristics of a human baby. This thought provoked the flood gates of ethics to unleash a multitude of unanswered questions and concerns about the usage and further development of genetic engineering. The field of genetic engineering is
(Glenn, Linda MacDonald, Ethical Issues in Genetic Engineering and Transgenics) There are many social and fundamental issues about genetically engineering organisms. The genetic modifyification of animal and human DNA results, intentionally or not, possesses degrees of intelligence or sentience never before tested. Instead of seeing the ‘subject’ of the experiment as a person or animal, they strip them of their rights and think of them as objects. Professor Nemur and Doctor Strauss did not care what happened to Charlie, as long as he provided the information and data they needed to make money and achieve fame. Social and legal controls should be placed on research like this. Who has the right to access these technologies and how will scarce resources (such as medical advances and novel treatments) be given out to experiment
Preventing genetic diseases has been one of the biggest factors when dealing with gene therapy and Designer Babies. Editing an embryo’s DNA allows scientists and parents to pick and choose the inherited traits for the potential child. As a result, Jayashree Das in the article “Redesigning Nature To Be or Not to Be?” claims that gene therapy simply “reduces the risk of genetic diseases and ensures that a defective gene gets obligated from the family line.” Many prospective parents with inherited diseases view gene therapy as an option to refrain from both financial and emotional strain. Furthermore, preventing these genetic diseases supports and protects children from suffering from these potential
On the last years, genetic technology have been improving. The research carried out in this area are focused on the early diagnosis of diseases. Moreover, manipulation of genes in the future provides a critical tool for eliminating fatal diseases to humans. Also humans will be able to manipulate genes from birth. But the real question is although can be perform it, we allow it? Everything possible is ethically permissible? Some dramatic demonstrations of genetic modification have been made with mice and other animals, however, evidence in humans are generally considered outside the ethical boundaries. Gregory Stock, director of the Program on Medicine, Technology, and Society at UCLA and author of Redesigning Humans, in his article “Choosing Our Genes” (2012) argues the use of technology to change humans genetic in order to avoid imperfections or diseases. Stock shows genetic engineering as a very useful technology and that applying it on the future to humans, positive results they will gain. Stocks article is effective, since he gives good reasons why using genetic technology would provide several benefits that people wish to have.
One field of genetic science which is crucial in society today is medicine where cloning is now possible. The need for moral reasoning is essential in this field because with greater power society must “[recognize] not only the limits of our knowledge but also our vulnerability to being misguided” with an evolving world (Dalai Lama 140). Humans have kept high moral responsibilities over the century when faced with new developments in knowledge. The Dalai Lama suggests that “our technological capacity has reached a critical point” during the past decade and the gap between knowledge and human ethics when making decisions has grown farther apart as new biogenetic science has arose (133). The issue is not whether
In the future, gene therapy could be used to alter genes that influence behaviour. There are two types of gene therapy: somatic gene therapy which modifies the DNA in the body, usually intargeted cells, and germline gene therapy where the reproductive cells are altered and the changes are transmitted to future generations (“Genetics and Human Behaviour: The Ethical Context”).
Deoxyribonucleic acid (DNA) was discovered in 1944 by Avery and colleagues. Avery identified DNA as the primary genetic material. Watson and Crick later discovered the double helix structure of DNA. Leder and co-workers deciphered the triple nucleotide code that designated the amino acids from which proteins were built. The science of molecular biology was born (Sokol, Gewirtz, 1996). In 1990 a four year old girl who was suffering from severe combined immunodeficiency (SCID) was the first to undergo gene therapy. White blood cells were removed from the girl and the cells were inserted with normal copies of the defective gene and returned into the girls circulation. Her condition improved with four treatments and
Just as there are different types of people who look at one glass of water and describe it as half full or half empty, the public has many different views on the future of our society. Gene therapy is also a glass that can be viewed in different angles – different perspectives. Some say it has great potential to shape the ideals of our future, while others believe it signifies intolerance for disabilities, imperfections that supposedly deplete from a person’s interests, opportunities and welfare (quoted by Peter Singer, xviii). This global issue has brought people with different opinions in the open, arguing their views using history,
Biotechnology interventions are used to advance human brains and our future to the extreme. The process of genetic engineering is very unpredictable and dramatic that it will have a major effect on its environment. Human genetic manipulation is considered unethical and dangerous for the most part. Human genetic alteration is illegal in many countries, but it is used in some places to cure gene diseases. The process of changing the genetic DNA of when a baby is born can be passed down the line of the persons. Swapping bad and unwanted genes for a better one is part of the process. There are many potential advantages gained from this operation as well as some dangers. Considering the ethical implications of the gene enhancement the result might cause a gene problem. The advanced technology application can make a huge different especially improving the quality of a human being by fixing an unwanted and inheritable gene defects. Many people are affected