The concept and definition of a gene, once considered concrete and established for decades, has recently come into question. Within approximately the past ten years, the research of numerous scientists has yielded results and observations inconsistent with what was considered a gene. Investigation of gene structure and function demonstrate that the concept of the gene needs reevaluation, particularly its qualification criteria (Marks and Lyles, 2005, cited in Portin 2009). Five major facts strongly support the necessity to refine the definition of a gene. First, there are no clear-cut boundaries of transcriptional units, and their complexity is apparent. Additionally, there is evidence to support pervasive genomic transcription from …show more content…
During the process of redefining the gene, it has to be considered how to refine a definition in order to be broad enough to account for all cases while still remaining a single idea (Portin 2009). Though there have been several proposed definitions, each comes with its own difficulties, such as taking into account regulatory elements and function of a gene. It has been proposed that a more systemic view should be taken when defining the gene, taking into consideration not only transcription factors but also those of regulation. By looking at the whole rather than simply parts, a holistic, more effective definition of the gene can be developed.
Discussion
The definition of the gene that has long been established is essentially useless now. It accounts for only a small portion of what is occurring and neglects the vast majority. A gene was a means to an end for coding proteins, and for quite a long time, that was acceptable. The protein coding sequences were what was seen important, while the rest was seen as “junk DNA” (Ohno 1972, cited in Gerstein et al. 2007). Function was defined as making a protein. While contrary evidence slowly emerged for a while, it was the ENCODE Project that materialized that the end all was not proteins, but that the nearly ninety-eight percent of the genome that does not code for proteins is also of significance and purpose. With new information constantly emerging and more
23.Genes have more than one job. They have multiple instructions to produce many proteins. If each gene had one purpose, there wouldn’t been enough to produce all the proteins needed for human life.
To make an analogy, a gene is like a conductor of orchestra who guides and provides information to the performers. Although the conductor does not play an instrument in the orchestra, his main role is to provide information about the musical piece that they are playing to shape the overall sound of music. Each orchestra is unique and distinguishable from other ensembles because they have different conductors with different musical interpretation. Also, each member of the orchestra is like a protein. Some play violin, some play flute, and some play brass, just like how each protein in our body plays different functions depending on where they bind, with whom they interact with, and how they catalyze a reaction. Although the proteins contain the same genetic information all around the body of an individual, their interactions with each other during development lead to a formation of different individuals with unique phenotype.
Though HAR1 was present in other species, it had evolved extremely slowly until the emergence of humans. “The fact that HAR1 was essentially frozen in time through hundreds of millions of years indicates that it does something very important; that it then underwent abrupt revision in humans suggests that this function was significantly modified in our lineage,” writes Pollard. HAR1 is named so because it seems to have rapidly evolved after humans and chimpanzees split from a common ancestor. HAR1 is also unique in that it does not encode a protein. Before the research done and discoveries made by the Human Genome Project, scientists previously thought that all genes required proteins as the building blocks to their sequencing. Researchers now know that these protein-encoded genes make up only 1.5 percent of our DNA. The other 98.5 percent – sometimes referred to as junk DNA – contains regulatory sequences that tell other genes when to turn on and off. “…You do not need to change very much of the genome to make a new species. The way to evolve a human from a chimp-human ancestor is not to speed the ticking of the molecular clock as a
Biodiversity is life’s variety. It is the varying genetics that each species carries that makes it different and “unique”. Biodiversity is important, not only in evolution, but in survival; when sometimes those terms can mean the very same thing. Interestingly, biodiversity can mean a variance in the life itself – or within the genetics of a species. In keeping breeding habits within the same lineage, some animals risk lower biodiversity and sometimes even deformities and disease, as they are able to more easily pass on unfavorable hereditary traits. In increasing the overall biodiversity, the only risk is a
The recently completed human genome sequence has greatly assisted the detection of QTLs and polymorphisms (2). It must also be emphasized that genes do not directly dictate action, but rather are mediated by the proteins that they code for. It is necessary to examine not only the genes but also the assortment of proteins responsible for expression of particular traits (3)It is anticipated that detailed analysis of the human genome will contribute to understandings about gene organization and transcription, and hence regulatory elements that control expression. By utilizing genomic and proteomic tools, the relationship between gene/protein and behavior may be more accurately described.
DeSalle and Michael Yudell. Welcome To The Genome: A User’s Guide to Genetic Past, Present, and Future. Canada: John Wiley & Sons. Inc., 2005. Print.
Summary and Comparison: A Psychological Interview Analysis of Levinson’s Life Structure Approach and Erikson’s Theory of Human Development Approach
Today’s society has an ever growing thirst for knowledge as we have for many hundreds of years now. Scientists work around the clock studying the affects of nearly everything they can think of to conduct experiments on. This quest for knowledge is the supposed start to a better life for man kind and ultimately a world without disease or hunger. The human genome project is one that has been going on for about 20 years. This project set out to map, down to the last detail, every part of the human DNA structure (“Human”). The project has recently been completed and the scientists are now starting another project with their newly found information, to cure mankind of its ailments.
trait by other genes or the environment) is the rule rather than the exception” (pp. 23).
Smoller also explains, “[t]hese resources create opportunities for focusing genetic studies on biological pathways…[in] evaluating the functional significance of risk loci that may [identify] in the future” (Smoller, p. 310). He also distinguished,
The Human Genome Project (HGP), an international scientific research project, has educated the public tremendously on various topics concerning DNA and genetics. This study has been beneficial to communities alike. As stated, the HGP sought to identify all the genes in human DNA, determine the sequences of the three billion chemical base pairs that make up human DNA, store this information in databases, improve tools for data analysis, transfer related technologies to the private sector, and address the ethical, legal, and social issues that may arise from the project. In favor of achieving these goals, scientists studied the genetic makeup of several nonhuman organisms (Human Genome Management Information System, 2011).
Dawkins' gene is a personified entity, seemingly to the extent that it is an independent being to an extent. The "machines", therefore, are subjected to programming of sorts by the genes. Capable of selfish and altruistic behavior, the gene "reaches" outside of the human body to interact with its environment (3). "With only a little imagination we can see the gene as sitting at the centre of a radiating web of extended phenotypic power," stated Dawkins (3). By granting "phenotypic power", the genotype (as determined by the interaction of genes) behaves in such a manner which dictates the phenotype, or physical expression of the gene. By following this pattern—interaction between the gene and its environment, it is arguable that the environment is actually governing genotypic behavior. By this, the environment is not merely a factor manipulated by the gene, but instead can manipulate the gene itself.
DNA is a term that has been used in science as well as in many parts of daily
The gene as the fundamental unit of heredity is the original meaning of the word as first geneticists intended it. This essentially explains the reason why, during last century, a burst of research occurred in the genetic field: it was carried out in order to discover the genes responsible for the most various traits, from the ones causing diseases to the ones responsible for genetic variation across populations. In fact, the scientific community was convinced that genes retained all the crucial information necessary for organisms’ generation, growth, survival and reproduction (Sarkar, 1998).
The Human Genome Project is a worldwide research effort with the goal of analyzing the structure of human DNA and determining the location of the estimated 100,000 human genes. In parallel with this effort, the DNA of a set of model organisms will be studied to provide the comparative information necessary for understanding the