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Gene Essay

Decent Essays

The concept and definition of a gene, once considered concrete and established for decades, has recently come into question. Within approximately the past ten years, the research of numerous scientists has yielded results and observations inconsistent with what was considered a gene. Investigation of gene structure and function demonstrate that the concept of the gene needs reevaluation, particularly its qualification criteria (Marks and Lyles, 2005, cited in Portin 2009). Five major facts strongly support the necessity to refine the definition of a gene. First, there are no clear-cut boundaries of transcriptional units, and their complexity is apparent. Additionally, there is evidence to support pervasive genomic transcription from …show more content…

During the process of redefining the gene, it has to be considered how to refine a definition in order to be broad enough to account for all cases while still remaining a single idea (Portin 2009). Though there have been several proposed definitions, each comes with its own difficulties, such as taking into account regulatory elements and function of a gene. It has been proposed that a more systemic view should be taken when defining the gene, taking into consideration not only transcription factors but also those of regulation. By looking at the whole rather than simply parts, a holistic, more effective definition of the gene can be developed.
Discussion
The definition of the gene that has long been established is essentially useless now. It accounts for only a small portion of what is occurring and neglects the vast majority. A gene was a means to an end for coding proteins, and for quite a long time, that was acceptable. The protein coding sequences were what was seen important, while the rest was seen as “junk DNA” (Ohno 1972, cited in Gerstein et al. 2007). Function was defined as making a protein. While contrary evidence slowly emerged for a while, it was the ENCODE Project that materialized that the end all was not proteins, but that the nearly ninety-eight percent of the genome that does not code for proteins is also of significance and purpose. With new information constantly emerging and more

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