I unmistakably recall my amazement as I watched my high school chemistry teacher balance an oxidation-reduction reaction on the board; in that moment, I became passionate about the molecular world. On the surface, the challenging coursework caught my curiosity, yet deep within was an internal connection to chemistry I had not experienced prior. This fascination with the molecular world was continually refined throughout my undergraduate coursework; however, no topic inspired me more than the molecular mechanisms underlying learning and memory in the brain. Shortly after, my first undergraduate research experience solidified my intuition to pursue a career investigating molecular mechanisms underlying conditions of impaired learning and …show more content…
Yet of the countless learning experiences encountered at IUPUI, none of these have better prepared me for the IBMG program than my research experience with Dr. Anthony Baucum.
In Dr. Baucum’s laboratory, I investigated a novel protein interaction between two scaffolding proteins, SAPAP3 and spinophilin. Spinophilin localizes to dendritic spines in striatal medium spiny neurons and plays an important role in regulating long-term depression (LTD), the molecular mechanism responsible for weakening the strength of a synapse. Interestingly, Dr. Baucum identified SAPAP3 as a novel interactor of Spinophilin through a proteomics screen. After conducting an extensive literature review, I noticed both of these proteins held a physiological relationship with metabotropic glutamate receptor 5 (mGluR5), a putative regulator of striatal LTD. Due to this connection, I investigated the role mGluR5 plays in regulating the interaction between these two proteins of interest using numerous molecular biology and biochemical techniques, such as PCR, mutagenesis, immunoprecipitation, western blot, and others. We determined that mGluR5, as well as its second messenger protein kinase C, increase the strength of this interaction. Through many experiments, we now hypothesize this novel interaction to regulate LTD in the striatum. After working on this project for two and a half years, a manuscript is now in
Bonnie Green, Chief Estimator, agreed that in a normal year only slight delays might develop due to a shortage of labor. However, she pointed out that for such a large project, the company would have to use unionized employees and that the construction industry labor agreements with New York City were to expire on October 30, 2004. Past experience and current construction activity in the surrounding area indicated that any union tradesman would support a strike against the city. Since this is a public project, she estimates that there is a 50% chance that they would strike this project to gain the attention of the national media.
“I got up and pretended to study the pictures on the walls like I was a lover of religious art. When I got to the Merciful Mother right above Sinita’s head, I reached in my pocket and pulled out the bottom I’d found on the train. It was sparkly like a diamond and had a little hole in back so you could thread a ribbon through it and wear it like a romantic lady’s choker necklace. It wasn’t something I’d do, but I could see the button would make a good trade with someone inclined in that direction.
Writing has many tools and devices that can be used to influence the purpose and meaning of the a piece of work. In the two pieces of work, "Private License Plate Scanners Amassing Vast Databases Open to Highest Bidders-which is written in a way that it is anti-license plate tracking- and "Who Has the Right to Track You?'-which is written to be for license plate tracking- many different tools and devices are used by the authors. These pieces of work describe the benefits and drawbacks of collecting data and tracking fellow citizens, but use different forms of pathos, ethos, and logos to portray what they are trying to say. Also, both articles state how many are opposed to this tracking, arguing that it is against the First Amendment,
The arguments I choose to assess for truth and validity will be three statements taken from the Application's list 12.2 (a -y) at the end of Ch. 12, “The Art of Thinking” publication. I will start with the statement (j) the premise that "power must be evil because it can corrupt people." Checking the argument for any hidden premises and ensuring it is stated fully and in a clear concise way is the first step. This argument seems to pass the first hurdle, however after checking for errors affecting truth, the argument has flaws. Beginning with, the part of the argument that says power corrupts people is not true
According to Henderson, “Historians of the new imperialism have tended to ignore the parallel histories of empire in nineteenth-century British North America”. He argues that in recent years, an increasing number of corresponding and connective histories have had the desire to locate early Canada as one site of an empire among others. He stresses how republicanism and a responsible government rely almost exclusively on published archival materials that have been used for a very long period (at least in Canada) by those who are interested in the history of the struggle for a responsible government.
I agree with Pacificus because the authority is given to the executive to preserve the peace in the nation, yet Overall I agree with the idea that the president’s power should not be limited for he is representing the entire nation.
While reading the story "Everyday Use" by Alice Walker, I found that I had a surprising amount of anger towards the character named Dee, or as she prefers Wangero. The anger that was instilled in me was caused by numerous comments and actions that occurred throughout reading the short story. I feel she was selfish, uneducated and unappreciative of her past and that the way she carried herself was ridiculous. Right from the beginning of my readings you are introduced to a character named Dee, before you ever get the opportunity to warm up to her character, she shows a very selfish characteristic and that trait is repeatedly brought out in the
President Trump has promised billions of dollars to Texas to help with the flooding from Harvey, but lately the Republican part of the House of Representatives has been asking Donald Trump over and over again to cut money off of the project and use it for the border wall. The House has been asking for about 876 million dollars to be cut from the project. But Donald Trump said that he would make Mexico pay for the wall, so no matter what happens, Donald Trump might not be in a good place.
Next, they address functional changes in the hippocampi with extracellular electrophysiological recordings of field population spikes on hippocampus slices. The calculated long-term potentiation (LTP) values of heterochronic parabionts, which reflect learning and memory abilities, remain above baseline level, while isochronic parabionts’ LTP values reach baseline level later. Synaptic strength shows no difference between the two groups. Villeda and co-researchers suggest that exposure to young blood improves synaptic plasticity level in aged hippocampi.
What have you heard in the news recently? Some people would mention Bitcoin, some would mention Net Neutrality. If we go back just a few months ago, Catalonia was at the epicenter of news. This was because a referendum about declaring independence from Spain was held, and the violence that ensued during it. This referendum showed that the majority of Catalans supported the idea of breaking apart from Spain to form their own independent nation, Catalonia. In this paper, Catalonia’s efforts to becoming an independent state will be looked at by two theories, realism and liberalism.
Inside the home, too often husbands offer no help whatsoever. They sit back and relax because, as far as they’re concerned, they’ve worked all day and when they get home it’s time to rest. When a mother gets home from her eight-hour job, she doesn’t come home to rest. She comes home to work some more, while a man sits somewhere waiting anxiously until the meal is put on the table. So, we don’t value her at all.