Surfactant is a surface-active substance that is made of lipids and proteins that cover the alveoli and stabilize it and also protect the lungs by reducing the surface tension of pulmonary fluids (the amount of energy that is required to increase the surface of a liquid due to its molecular interaction bonds), that’s why alveoli don’t collapse when gas is exchanged in and out of the body (1). Phospholipids take up 80-85% of surfactant’s weight, and 40-50% is in form of disaturated (dipalmitoylphosphatidylcholine, DPPC). DPPC is in control for the surface tension decreasing the capability of surfactant. Surfactant is also composed of phosphtidylglycerol, phosphatiylethanolamine, sphingolmyelin, and cholesterol. Phospholipids in surfactant
The presence of fluid in the alveolar space could potentially cause the lung capacity to be effected as well.
This experiment was conducted to show the importance of a surfactant using common household items and demonstrating how surface tension works in the respiratory system. Surface tension, according to Marieb and Hoehn, is when water molecules in the alveoli lining are attracted to each other and draw each other to a smaller dimension (Marieb & Hoehn, pg. 715). This means that this type of attraction can pull the lungs inward and cause them to collapse due to the attraction of molecules, but other opposing forces prevent them from staying that way, such as the lung’s ability to produce a fluid that reduces
The simple act of breathing as we know it, is not as simple as it seems. Breathing takes numerous organs and requires a variety of complex operations to correctly occur. One of the most unique factors of breathing is pulmonary surfactant. Pulmonary Surfactant is an oily fluid that is composed of a mixture of lipids and protein molecules that coats the inner alveolar surface (McKinley, 2016). The internal surface of alveoli is moist, which makes it prone to collapsing because of its high surface tension, pulmonary surfactant keeps the alveoli and lungs from collapsing (McKinley, 2016).
Surfactant is an essential component for the respiratory system to function properly. Knowing the physiology of surfactant in the alveoli is important to know when learning the structure of the air sacs and how they work. This experiment is designed to make the understanding of surfactant in the alveolar film easier to learn, because it's not very simple. Surfactant is a detergent-like substance produced by the Type II alveolar cells in the walls of the alveoli. Surfactant is produced to reduce the surface tension of the water molecules that primarily compose the walls of the alveoli. For this experiment, we will be using milk and food coloring to represent the water (milk) and gas (food coloring) in
movement of water in tissues and maintain the fluidity of mucus and other secretions [3].
Ventolin is a name brand, prescription medication that is prevalent among asthmatics. Its molecular structure is referred to as salbutamol and is sold with both enantiomers of the molecule in a racemic mixture. Ventolin is used to treat asthma, exercise-induced bronchospasms and even help with chronic obstructive pulmonary disorders (COPDs). This medication can be administered or taken with an inhaler, nebulizer, pill or even an intravenous solution. In order for this medication to take effect and induce bronchodilation, it must undergo a series of steps. For the purpose of exhibiting the use of Ventolin, we will analyze its use via inhaler, on a person having an asthma attack.
RDS is caused by a defective or delayed production of surfactant in structurally immature lungs. Surfactant is a complex mixture of phospholipids and proteins secreted by the type
which it is absorbed by alveoli. Alveoli is where gas exchange happens by tiny air sacs. THC
ANP plays important role in vasodilation, bronchorelaxation, pulmonary vascular permeability, and surfactant production and action in the airways. It also may have bronchoprotective effects in an asthma attack because it has been found in
In conclusion, the purpose of this experiment was to show how “[t]he main function of surfactant is to lower the surface tension at the air/liquid interface within the alveoli of the lung. This is needed to lower the work of breathing and to prevent alveolar collapse at end-expiration” (Veldhuizen and Haagsman). Although the blue food coloring moved slowly at first, I did not anticipate it would be forced to submerge and move at its own pace. However, when the surfactant was added, it forced the blue food coloring to move at faster rate pushing up and out to integrate with the rest of the water particles changing the entire contents of the petri dish. Surfactant is important to help breakdown and decrease the surface tension allowing the gases
Within this assignment, I will be looking at how materials are exchanged across the cells membrane. I will be explaining the processes, diffusion, osmosis, active transport and phagocytosis. My assignment will also explain how these exchanges are related to the cell membranes structure and, explain the movement of water from cells using the concept of water potential. Diffusion Diffusion is the process by which molecules spread from areas of high concentration, to areas of low concentration.
Surfactant is an essential component for the respiratory system to function properly. This experiment was done to better understand the functioning of a surfactant. The reason why a surfactant is needed is to reduce the surface tension of the water molecules that primarily compose the walls of the alveoli. We used milk and food coloring to represent the water and the gas in the respiratory system. The milk was placed in a petri dish and drops of food coloring were added into the milk at the center of the dish.
The reason being is because when infants are born premature, their lungs have not had the time to produce enough surfactant for them breathe in air like a normal full-term infant. The surfactant is a liquid that coats the inside of the lungs to keep them open, enabling them to breathe in air easily once they are born.
The most serious of these being hyaline membrane disease (HMD), most commonly known as RDS or respiratory distress syndrome. Babies that suffer from this condition will tend to find it very difficult to breathe due to the increased surface tension and the ultimate lack of oxygen transported through the body can seriously impair and damage the functions of the brain and other organs of the baby. Surfactant deficiency’s can also sometimes be caused by mutations in a particular gene. An example of this is surfactant protein or SP-B deficiency. This particular dysfunction is hereditary and is caused by a gene mutation on chromes number two. Babies that suffer from tis condition rarely survive past a few months. However there are some procedures that can help babies who may have been born prematurely and have not manufactured enough surfactants to support regular functions. Surfactant replacement therapy and surfactant supplements are amongst the most popular treatments of these types of surfactant deficiencies in newly born
There are several factors that oppose and promote alveolar collapse, including the transmural pressure gradient, pulmonary surfactant, alveolar interdependence (all opposing factors), alveolar surface tension and the elasticity of stretched pulmonary connective tissue fibres (promoting factors). I will discuss these different aspects of lung physiology here.