1.0 INTRODUCTION
Based on United State Pharmacopeia, pastes are defined as semisolid dosage forms that contain one or more drug substances intended for topical application. (Pharmaceutical Dosage Form, 2009) Pastes are also intended for application to oral cavity or mucous membranes besides the skin. Pastes are usually prepared from fats, fatty oils, petrolatum, paraffin, waxes, glycerin or water by mixing homogeneously powdered drug with the foregoing materials as bases. (General Requirements for Pharmaceutical Preparation) There are two classes of paste which are fatty pastes and non-greasy pastes which is made from single phase aqueous gel.
Although the preparations of pastes are similar to ointment, there are still having differences between paste and ointment. Compared to ointments and gels, pastes contain a high proportion of finely powdered medicaments. Pastes are generally composed of ointment bases that contain a high concentration (frequently 50%w/w) of dispersed drug. Hence, the viscosity of pastes is higher than that of pharmaceutical ointment. The base for pastes may be anhydrous (liquid or soft paraffin) or water soluble (glycerol or mucilage). (Prashant, 2010)
Furthermore, pastes take some advantages over the ointments. Pastes are more often used for protective action compared to ointments. This is because pastes ordinarily do not flow at body temperature so it can serve as protective coatings. Fatty pastes that have a high proportion of hydrophilic solids
The lab checked for neutralization and check if it did not neutralize too much or too little. There were two commonly sold brands examined in this lab which were the Tums and Rolaids. The crushed tablets were dissolved in 0.10 M HCl with a pH indicator bromophenol blue and a solution of KOH was added to it in order to neutralize the solution. The solution turned light blue when it was neutralized. Both the tablets were neutralized and titrated in the same way. From the observations above; Rolaids was better because it had better neutralizing ability per each dollar spent than the Tums. As the Rolaids were 4.07g/$ and the Tums were 4.01g/$ as seen from the observations above. So, the better buy is the Rolaids out of the two as the neutralization ability per dollar spent in the Rolaids is better than the
It absorbs and reflects light, including ultraviolet radiation from the sun, which can cause products to worsen and lose their pigment. Talc, hydrous magnesium silicate (MgSlO4) is used as an absorbent, anti-caking agent. It improves the feel of the product and helps smooth or soften them. Metallic stearates (C17H35CO) also known as stearate salts are used for their moisturizing properties. They help keep the mixture of two or more liquids from separating into their oil and liquid components. The stearate salts increase the thickness of the liquid and reduces the transparent appearance of finished products. Lecithin (C42H82NO8P) or hydrogenated lecithin help cover the appearance of dry or damaged skin by reducing flaking and restoring flexibility. It also has skin-restoring abilities. Sulfosuccinate (C20H37NaO7S) helps the water solubility of other cosmetic ingredients. It also helps form the unblendable mixtures by reducing the surface tension of the substances, which is known as a cleansing agent. Ethoxylated alcohol (C26H50O10), functions as a surfactant and are used as cleansing agents. They clean the skin by helping water mix with oil and dirt so they can be washed away. It also acts as a skin conditioning agent. Bentonite (Al2O34SiO2H2O) has many purposes. It 's used for smoothing, polishing, or abrading other chemicals in the foundation. Helps hold together all of the ingredients. Acts as an absorbent. Increases the volume of a
*Topical application administration - This is where creams, ointments and gels are applied directly to the skin. They can be used to treat skin conditions or can be used as a delivery route for an analgesic (a painkiller)
William James Mayo once said “The glory of medicine is that it is constantly moving forward, that there is always more to learn. The ills of today do not cloud the horizon of tomorrow, but act as a spur to a greater effort.” Medical advancements have helped us live longer by being able to cure the ills we face. Bioprinting synthetic skin has impacted the way we live by being able to treat skin injuries in many different ways, ability to treat severe burns and benefits synthetic skin has towards cosmetic industry.
I believe that the tablet takes longer to give the body and system the relief feeling and the injectable liquid spreads quicker and makes you feel better.
Topical medications come in the form of creams and gels and are applied directly to the skin surface usually to treat skin conditions.
OTC contain low levels of medicated ingredients for killing bacteria, controlling excess oil and shedding dead skin cells.
Topical drugs such as patches, ointment, and cream are applied directly on the skin and can be absorbed fast or with a delayed action. The term pharmacokinetics is the study of the movement of the drug in the human’s body. This includes the site of absorption (movement of drug from entry to tissue), how it is distributed (movement in the circulatory system to intended destination), how it is metabolized (break down in the liver), and excretion (elimination from the body). This unit also described the term half-life, which is how long the human body takes to break down a drug, absorb and excrete it and short half-life, which are medications excreted by the body quicker than long half-life drugs. The term pharmacodynamics is any of the changes in the patient’s body resulting from the medicine taken. It is highly important for the patient to know of the used drug’s side effects (unintended effects), adverse effects (unintended effects that can be harmful), and any possibilities of allergic reactions (most severe adverse response of a
In injections, active ingredients are dissolved in a liquid and then injected. A drug is often injected into a vein (intravenous administration) if it is to have as fast an effect as possible, for instance in an emergency.
Topical-This would be a type of medication applied to the surface/skin on the body i.e. creams, foams gels,
They provide cleaning properties of pastes. The use as abrasives, calcium carbonate, and sodium bicarbonate (baking soda and chalk), which is too aggressive for children's tooth enamel. Milder cleansing have titanium dioxide and silicon dioxide, and their presence in the composition of the paste is more desirable. Designation of abrasion on the packaging of paste - index RDA, which must be not more than 20. For children up to 4 years, no more than 50.
Cosmetics are substances that are applied onto the body and/or face to enhance a person’s looks or scent. Cosmetics can be make-up which is mostly used by women and it is to enhance a female’s appearance. It is normally applied to face, hair, and body. Cosmetics has been used throughout society since Ancient times. In Ancient Egypt, cosmetic chemistry was being used before anyone knew it related to chemistry. Cosmetics was being used for many reasons in Ancient times. It is said that Cleopatra bathed in donkey milk to keep skin smooth, this is an example to show that chemistry is being used for the benefit of skin care. Skin care is another example of cosmetic chemistry being used. Skin care has been an important factor in society. Skin care has been around since 3000 BC in Ancient Egypt. This was prepared by natural materials.
I chose my topic because I have a skin condition, and I thought it might be a good idea to research different skin disorders. I have eczema on my foot and it was a very irritable skin disorder to go through. But thanks to the miracle of modern day medicine, all I'm left with is a scar and it is barely noticeable. Since that's my skin disorder I will begin with eczema and work my way down to pressure sores.
There are hand creams designed for different purposes. Most people use hand lotions for dry skin, usually in the winter time. Lotions soften the hand and it looks more visually appealing. Some people use lotions because they have eczema, and lotion prevents it from flaring up. Others may use
Our skin is the largest part of our body and needs constant care and miniaturization to achieve a healthy glow. First thing to healthy-looking skin is maintaining an internal regimen; drinking lots of water and eating fruits and veggies will keep skin nourished, moisturized and blemish free.