The treatment of malaria is governed by a variety factors which determine the ability to successfully eradicate this disease. It is important to treat malaria as soon as possible if experiencing the related symptoms. Identifying the species of parasite is a major factor when deciding the correct treatment to use, the location of infection is equally important as well. In certain areas of the world, treatment with antimalarial drugs has become ineffective due to resistance of the parasite. Therapy with antimalarial drugs is the lone treatment that will successfully eliminate the disease. These can be administered as a monotherapy, where resources are limited, and as a more effective combination therapy. In most cases administration is …show more content…
falciparum emerged. Today these resistant strains occur in endemic areas excluding Central America, Mexico, china, and the Middle East. Multidrug resistant strains occur in Southeast Asia, South America, and sub-Saharan Africa. Resistance to P. vivax strains has also emerged originating in New Guinea and Oceania where documented reports have shown complete failure. Chloroquine resistant Infections in most of Africa, parts of Asia, and South America are treated effectively with a single dose combination treatment of sulfonamide and pyrimethamine. There are three main alternatives for Chloroquine resistant strains of P. falciparum: 1) A combination therapy of oral quinine and tetracycline, doxycycline, or clindamycin, 2) Combination therapy of Atovaquone-proguanil, and 3) monotherapy treatment with mefloquine.
During the 1980s mefloquine emerged as the successor to chloroquine monotherapy. However it is portrayed negatively through the media due to associations with suicides, homicides, and personal tragedies. Studies show that high efficacy is seen in patients on the western boarder of Myanmar, and moderate efficacy of infected patients in Bangkok and Bangladesh. These patients were free of parasitemia after a 28-day period, showing no incidences of recrudescence. There is a higher prevalence of resistance to P. falciparum infections acquired in specific areas including: the boarders of Thailand, eastern states of Burma, western provinces of Cambodia, the border
PROMETHEUS AND GAEA: CONNECTIONS TO ANTHEM According to the Dictionary of Greek and Roman Biography and Mythology, Prometheus was the Titan god of forethought. As a Titan he was given a task to make mankind out of clay. After the task was done, conflict was brought between him and Zeus. This conflict was established when Prometheus stole fire from Zeus and gave to the man down on Earth.
"St. Michael the Archangel" For my saint, I picked Saint Michael the Archangel. I picked St. Michael because Michael is my middle name. Saint Michael is a name meaning "He who is like God" in Hebrew. He is said to be placed over all the angels. He is the Patron Saint of soldiers, security guards, and sick people. Saint Michael is one of the seven archangels, him being one of the three mention in the Bible. He is the leader of the army of God during the Lucifer upraising. It is said by Pope Gregory the Great "Whenever some act of wondrous power must be performed, Michael is sent, so that his action and his name may make it clear that no one can do what God does by his superior power." Saint Michael is one of the principal angels. In Latin,
Brian, G, Y., Greenwood, D, A., Fidock, Dennis, E, K., Stefan, H, I. Kappe, P., Alonso, L., Frank, H and Collins, P (2008) “Malaria progress and prospects for eradication.” Journal Clinical Investiment. 118: 1266-1276.
There have been many attempts at preventing malaria, none of which have been very successful. These have usually involved protecting human beings from mosquitoes, the dreaded carriers
The symptoms vary because patients are diagnosed with having either uncomplicated or severe malaria. This is due to the fact that different kinds of malaria range in severity. For instance, ,P. falciparum and P. knowlesi infections can cause rapidly progressive severe illness and lead to death death while the other species, P. malariae, P. vivax, or P. ovale are less likely to cause such severe manifestations. Furthermore, P. vivax and P. ovale infections also require treatment for the hypnozoite forms that remain dormant in the liver and can cause a relapsing infection. Finally, P. falciparum and P. vivax species have varying drug resistance patterns in different geographic regions. For P. falciparum and P. knowlesi infections, the urgent initiation of appropriate therapy is especially
Chloroquine (Aralen): The most commonly prescribed antimalarial medication in countries where there are no drug resistant strains of malaria. This drug is taken once a week, from one to two weeks prior to travel, until four weeks after you
Malaria is considered one of the most serious and life-threatening public health problems in the world. According to World Health Organization, more than 3 billion people live in areas classified as being at risk from malaria, with nearly 200 million cases.1 Approximately, 750,000 deaths occur every year, primarily among children, due to malaria and its complications.1 Children less than 5 years of age are more vulnerable to be affected by malaria.2 In 2015, about 438,000 malaria deaths were reported, of which estimated 69% were children under 5 years of age.2
Malaria has been plaguing societies for years. Only recently has the Unites States and other countries been able to make it a rare instance due to control of mosquitos. The symptoms of malaria was first described in Chinese writings, the Nei Ching (2700 BC). It became widely known in Greece, Hippocrates noted the principle symptoms. In the Susruta, a Sanskrit medical treatise, the symptoms of malaria were described and attributed to certain bites of insects. Some Roman writers thought the diseases were attributed to swampy areas. In the New World, Indians told Spanish missionaries of the medical bark they used to treat the fevers of those infected with malaria. With the bark it actually cured the wife of the Viceroy of Peru. After this the bark from that tree was called Cinchona after the countess. The antimalarial, quinine, derives from this bark and
According to the health and environment, Malaria is a universal contagious disease and also a tremendous social complication all around the world, especially in South Asia, and Africa. Approximately, 3 billion of the community are in danger of infection in 109 regions. Every year, there is a prediction of 250 million compacts of miasm prominent to 1 million annihilations, particularly adolescents under 5 years old. The structure that causes the greatest unhealthy form of paludism is a imperceptible parasite that is known as the “Plasmodium falciparum”.
After infection malaria can sit dormant for up to a month while other species of the parasite will will cause a shorter period of dormancy, typically lasting from a couple of days to seven days. After the dormant or incubation periods have finished is when the disease starts its symptoms. Diagnosis is confirmed usually by manual microscope blood sample analysis. While there are a number of different kinds of anti-malarials, one kind, called “chloroquine” is mainly used. If treated urgently and correctly, the prognosis of malaria is very good for most of the plasmodium types. P. falciparum can be a bit of a problem, but is also usually not fatal. The reason malaria is so fatal is because people who contract, especially in the third world, do not always have a means to seek medical care.
After I have interrupted the royal wedding of Snow White and Prince Charming, Snow is furious. Charming suggests that they ignore me and go on a honeymoon. At first Snow does not believe it is the right time but then has a change of heart and agrees. She suggests they honeymoon at the Summer Palace which is where her parents had gone. As soon as Charming leaves her Grumpy comes to her and tells her the palace is now secure. He asks if she really believes it is a good time to leave. Snow tells Grumpy there is something at the Summer Palace that will help her.
Treatment of malaria is largely dependent upon the severity of the case. At this current point in time there is still no actual vaccine for malaria so it is instead treated. In the un-advanced, uncomplicated stages, it tends to simply be treated with anti-malarial oral medications. These include Chloroquine and Artemisinin, with the most common being artemisinin. This particular drug is the most effective and has shown to have significant improvements in conditions in just one to three
Malaria is a protozoa disease transmitted by the bite of infected Anopheles mosquitoes. It is the most important of the parasitic diseases of humans. Malaria transmission see in 107 countries, and killed more than 3 million people each year (According to World Health Organization 209 report). Sub-Saharan countries are the most malaria affected area in the world. It is transmitted from person to person by the bite of infected female Anopheles mosquitoes. Malaria is most common in poor and deprived areas. The principal determinants of the epidemiology of malaria are the number (density), the human-biting habits, and the longevity of the anopheline mosquito vectors. There are four species of the genes Plasmodium types of Malaria, which are plasmodium vivax, falciparum, and ovule; among them vivax is most common and predominantly found in Central America. P. ovule is mostly found in sub-Saharan Africa, but in recent year studies show that there is much less common. Even though there is a promising signs that shows a control of diseases transmission more than 50%, still remains a heavy burden on tropical communities, a threat to non-endemic countries, and a danger to travelers.
In terms of preventative treatment, malarial prophylaxis may be suppressive or causal with the primary distinction being the former affects blood stage infections only while the latter can affect parasites in both the liver and blood (Lopez Del Prado et al., 2014). Some examples of suppressive prophylaxis include doxycycline, mefloquine and chloroquine while causal prophylaxis may be drugs like malarone and primaquine. Chloroquine is typically used in the treatment of non-falciparum malaria as resistance has been spreading especially in endemic areas with previously high use. The specific regimen used and its dosage depends on the individual taking said medication and the region to which they travel (Lopez Del Prado et al., 2014).
Malaria is a disease whose effects can be felt worldwide. Not only does the disease touch adults, unfortunately the major population affected by the disease is children under the age of 5yrs old and pregnant women. Malaria is the third largest killer of children worldwide. The number of malaria related deaths per years has decreased through the years form 300 million cases worldwide in 1999 to 198 million cases in 2013, also malaria related deaths have decreased by a sum of 60% from the year of 2000 to 2015, however the number of deaths (438,000 in 2014) is extremely high and can be drastically lowered or even diminished completely with the right resources. These resources have proven to be available and successful in some particularly wealthy areas of the world including Brazil, Eritrea, and Vietnam, yet malaria is still very prevalent and fatal in others namely Kenya, Nigeria and Rwanda. The question is why? What roles does government play in this international issue? What steps can be taken to rid the world of malaria completely?