Cardiomyophysiology Of Heart Failure

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Patients presenting Symptoms: Gradual onset of dyspnea on exertion, fatigue, frequent dyspepsia with nausea and occasional epigastric pain, trouble breathing while lying on his back and, which is relieved by sitting up (orthopnea), an hypertension.

Morita (2005) stated that ‘recent insights into molecular genetic causes of myocardial diseases have highlighted the importance of single-gene defects in the pathogenesis of heart failure’. The information we can collect from investigation of gene defects, and an understanding of how genetics contributes to the development of heart failure, will ultimately help in prevention, treatment and possibly cure of cardiomyopathies in the future but we must also consider the environmental factors role.

Heart failure affects nearly 6 million Americans. It is the leading cause of hospitalization in people older than 65. Roughly 550,000 people are diagnosed with heart failure each year (Emory Healthcare, 2014). Heart failure is a pathologic state where the heart cannot pump enough blood to meet the demand of the body’s metabolic needs or when the ventricle’s ability to fill is impaired. It is not a disease, but rather a complex clinical syndrome. The symptoms of heart failure come from pulmonary vascular congestion and inadequate perfusion of the systemic circulation. Individuals experience orthopnea,

Dilated cardiomyopathy (DCM) is a disorder caused by abnormalities in functional regions of the heart muscle. [Maron et al., 2006] It is one of two major types of cardiomyopathies, the other being hypertrophic cardiomyopathy (HCM). In DCM the ventricles are dilated with dysfunctional systolic pressure, affecting 1 in 2500 individuals. [Codd et al., 1989, Pahl, 2010] Familial DCM is diagnosed when two or more family members die or there is sudden death of a child due to DCM. [Mestroni et al., 1999] The end point for DCM is heart failure. [Pahl, 2010] Mutations in over 30 genes have been identified as the main causes of familial and sporadic DCM (~ 33% of cases) [Gru ̈nig et al., 1998; Jefferies et al., 2010; Macara 2001; Michels et al., 1992;

The pathophysiology of congestive heart failure is that the heart has a loss of contractibility. This causes a lack of cardiac output which can’t meet the demands of the body. CHF can be caused by multiple different factors such as loss of muscle, abnormal rhythm or volume overload. CHF often occurs in patients who have multiple comorbidities such as hypertension or diabetes

Intro- Heart Failure is a multifactorial disease due to significant diminishing of heart pumping action. This is occurs in response to many underlying disease such as diabetes, hypertension, myocardial infarction and cardiac myopathies. These conditons lead to hemodynamic instability, neuroendocrine imbalances and structural remodeling of cardiac myocytes. Early less sever hf allows for compensatory mechanisms such as neuroendocrine stimulation- (beta adrenbergic r endothelin norepinephrine r), and hypertrophy which allow for sufficient left ventricular pumping action. However as hf develops these mechanisms become unable to compensate for the progressive underlying disease which results in further loss of contraction and relaxation efficiency and loss of regulation.

Heart failure (HF) is a complex syndrome in which structural or functional cardiac disorders impair the ability of one or both ventricles to fill with or eject blood. HF is considered to be a chronic condition with periods of worsening symptoms that may require medical attention. It may present acutely within just 24 hours in the form of pulmonary edema or even cardiogenic shock. To diagnose HF, three criteria need to be present: including shortness of breath at rest or during exertion and/or fatigue, signs of fluid retention such as pulmonary congestion and/or ankle swelling, and objective evidence of a decrease in myocardial performance at rest which is demonstrated using echocardiography.(1)

Heart Failure is a progressive heart disease when the muscle of the heart is weakened so that it cannot pump blood as it should; the blood backs up into the blood vessels around the lungs and the other parts of the body (NHS Choice, 2015). In heart failure, the heart is not able to maintain a normal range cardiac output to meet the metabolic needs of the body (Kemp and Conte, 2012). Heart failure is a major worldwide public health problem, it is the end stage of heart disease and it could lead to high mortality. At present, heart failure is usually associated with old age, given the dramatic increase in the population of older people (ACCF/AHA, 2013). In the USA, there are about 5.7 million adults who have heart failure, about half of the people die within 5 years of diagnosis, and it costs the nation an estimated $30.7 billion each year (ACCF/AHA, 2013).

s your topic based on patient education and medication compliance in heart failure patients to improve their condition? Also, what type of research method was used for each of the sources, is it quantitative or qualitative? The difference between the two is that “quantitative studies is between experimental research, in which researchers actively intervene, and nonexperimental research in which researchers make observations of existing phenomena without intervening” (Beck & Polit, 2012, p. 69). I think this topic is an important and interesting one because many of the patients I come across have heart failure. I would be interested to see what types of interventions were used in the studies to increase compliance and how this was measured.

Heart failure is a major health problem worldwide, but especially in the United States. The CDC estimates that over 5.7 million Americans are living with heart failure, and that

Heart failure (HF) is defined as a multifaceted clinical syndrome that can result from any structural or functional cardiac disorder that impairs the ability of the ventricle to fill with or eject blood. In HF, the heart may not provide tissues with adequate blood for metabolic needs, and cardiac-related elevation of pulmonary or systemic venous pressures may result in organ congestion1. In the United States, HF is increasing in incidence with about 5.1 million people suffering from HF and half of people who develop HF die within 5years 2. Over 75% of existing and new cases occurred in individuals over 65 years of age, < 1% in individuals below 60 years, nearly 10% in those over 80 years of age. HF costs the

Heart failure is term that is used to describe the heart’s inability to work efficiently as a pump. In order to decipher if an individual is likely to have heart failure is through their health history. Common backgrounds associated are diabetes mellitus, kidney dysfunction, hypertension, chronic lung disease, angina, myocardial infarction, and ischemic heart disease (Kirk, 2011). It is accompanied by shortness of breath on exertion, decreased exercise tolerance, paroxysmal nocturnal dyspnea, orthopnea, ankle swelling, sudden weight gain, lack of appetite or nausea and difficulty concentrating (Kirk, 2011). In worsening conditions it could progress to fluid buildup, rapid or irregular heartbeat, chest pains , and sudden

Almost every one in the United States knows a person suffering from congestive heart failure. This disease has manifested its way into the lives of so many—the statistics are astounding. According to the National Heart, Lung and Blood Institute, nearly 5 million people are affected and it is the main reason for hospital admission in older adults over the age of 65. This is a great cause for concern. In order to reduce the morbidity and control this epidemic, we must first understand the risks and causes of this condition. It is of the upmost importance to first understand the risks and causes of this condition. Education plays a key role in order to recognize the clinical manifestations and necessary actions to best treat

As the population ages heart failure is expected to increase exceptionally. About twenty-two percent of men and forty-four percent of women will develop heart failure within six years of having a heart attack. “Thirty years ago patients would have died from their heart attacks!” (Couzens)