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Campylobacter Infection

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Campylobacter species are one of the most prevalent and widespread bacterial enteric pathogens in both industrialized and developing countries [1]. It account for most cases of human gastrointestinal infections worldwide, causing 400-500 million cases of diarrhea each year [2]. In the European Union (EU) in 2008, 190,566 cases of campylobacteriosis was confirmed [3], while in the United States (USA), an estimated 2.4 million incidents occur each year [4]. A total of 220,209 Campylobacter cases were reported and confirmed by the EU in humans in 2011, and 212,064 established cases in 2010 [5]. In developing countries, Campylobacter-related gastroenteritis rates are most common amongst children less than five years old [6]. Campylobacter infection is primarily a zoonotic disease as it is a commensal of food animals, particularly poultry, which serves as the main reservoir for human infection [7]. Other sources of transmission, include water, milk, and food animal meat products [8]. The disease characteristics vary from watery, non-bloody, non-inflammatory diarrhea to a severe inflammatory diarrhea followed by abdominal pain and fever [9]. Amongst …show more content…

However, the emergence of antibiotic resistant strains poses a challenge in the management of Campylobacter infections. Isolates of C. jejuni and C. coli with resistance to various antimicrobial agents have been reported in both developed and developing countries [12]. There is a dearth of surveillance systems/data? on clinical Campylobacter in South Africa, particularly in the private healthcare environment. We therefore investigated the prevalence of resistance against ciprofloxacin and erythromycin, as well as against newer antibiotics in these classes, viz., gatifloxacin, azithromycin and tetracycline in clinical Campylobacter isolates from a private pathology laboratory in South

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