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Caffeine Citrate Research

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In Accordance to our survey question number 13 asks when should the drug be stopped? There where 78 responders 53 responders (67.95 %) replied tachycardia, 6 responders replied vomiting (7.69%), 12 responders (15.38%) replied feeding intolerance, 8 responders replied jitteriness(10.26%) and the 21 responded other. Moreover, the respondents that replied other had Tachycardia as the highest number thus this accounts for the highest overall respondents which believed that the drug must be stopped if the caffeine cause the heart rate to increase more than 200bpm. 4 respondents said necrotizing entercolitis (NEC) was the primary reason the drug should be stopped. Followed by two respondents that said both tachycardia >200bpm and NEC. …show more content…

A double blind randomized control trial conducted by Mohammed S et all (2015)., aimed to prove that using a higher, than current standard, loading and maintenance doses of caffeine for treatment of apnea of prematurity is well tolerated, may decrease the chance of extubation failure in ventilated patients, and significantly decrease the frequency of apnea. Moreover, the high-dose of caffeine was associated with significant increase in episodes of tachycardia (p < 0.05) without a significant impact on physician decision to withhold caffeine. In addition to that, no increment in the rates of NEC in preterm infants after receiving a loading dose of caffeine citrate of 20 mg/kg per day followed by maintenance doses of 10 mg/kg per day compared to standard-dose regimen. [55]. https://link.springer.com/article/10.1007%2Fs00431-015-2494-8 A retrospective study included 89 patients, illustrated that there was a low incidence of tachycardia attributed to caffeine therapy, with 9 infants experiencing one episode of tachycardia and 2 infants experiencing three episodes (Figure 7). In addition to that, the critical threshold for serious toxicity with caffeine therapy is >50 mg/L. Suzanne J. Francart et all (2013). An article written by Gian Pacifici (2014), revealed that jitterness occurred in an infant with plasma concentration level of 61.7microgram/ml, and toxic effects start to show at levels ranging from

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