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Airway Disorders: What Does Asthma Causes

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Asthma causes may include allergens, environmental irritants, respiratory illnesses, sulphites in food, reflux, or medications like beta blockers.2 The airways of asthmatics are narrowed due to the plugging by accumulated mucus, and smooth muscle contraction. During inspiration, the diaphragm moves downwards into the abdomen, and the ribs move upward and outward movement due to diaphragm and inspiratory intercostal muscles’ contraction respectively. This enlarges the lungs due to the changes in intrapleural pressure, and expands the alveoli. Hence, airway resistance decreases during inspiration, because, as the lungs enlarge, the airways within the lung are subject to the same forces as the alveoli, becoming widened. During passive expiration, the inspiratory intercostal muscles relax, causing the lungs to recoil. During active expiration, expiratory intercostal muscles and abdominal muscles contract, decreasing thoracic dimensions, and increasing …show more content…

Adrenoceptor agonists relax airway smooth muscle, and inhibit the release of bronchoconstricting mediators from mast cells. They can also increase mucociliary transport via increasing ciliary activity, and inhibit microvascular leakage. These are achieved through stimulation of adenylyl cyclase, which increase the formation of intracellular cAMP. 2-selective drugs include ephedrine, albuterol, terbutaline, pirbuterol, salmeterol, formoterol, and indacaterol. Anti-inflammatory agents such as an inhaled corticosteroid can provide long-term control. These inhibit the production of inflammatory cytokines, and the infiltration of asthmatic airways by mast cells, lymphocytes, and eosinophils. If taken frequently, these decrease bronchial reactivity, and reduce the frequency of asthma exacerbations. Some inhaled corticosteroids include beclomethasone, budesonide, flunisolide, ciclesonide, fluticasone, mometasone, and

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